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苏循成课题组开发了一个使用5-氟-4(苯基磺酰基)吡咯醛(FPPA)介导的蛋白质偶联方法。
18. A reactive, rigid Gd(III) labelling tag for in-cell EPR distance measurements in proteins. Yang Y, Yang F, Gong Y. J., Chen J. L., Goldfarb D., Su X. C. Angew. Chem. Int. Ed. Engl. 2017, 56, 2914-2918.
17. Deciphering the multisite interactions of a protein and its ligand at atomic resolution by using sensitive paramagnetic effects. Ma F. H., Wang X, Chen J. L., Wen X, Sun H, Su X. C. Chem. Eur. J. 2017, 23, 926-934.
16. Single-armed phenylsulfonated pyridine derivative of DOTA is rigid and stable paramagnetic tag in protein analysis. Yang F, Wang X, Pan B. B., Su X. C. Chem. Commun. 2016, 52, 11535-11538.
15. 3D Structure determination of an unstable transient enzyme intermediate by paramagnetic NMR spectroscopy. Chen J. L., Wang X, Yang F, Cao C, Otting G, Su X. C. Angew. Chem. Int. Ed. Engl. 2016, 55, 13744-13748.
14. Researchers solve protein structure inside living cells for the first time Now, a researcher team led by Xun-Cheng Su from Nankai University in Tianjin, China, Conggang Li at Chinese Academy of Sciences, and Thomas Huber from the Australian National University, has analysed a protein’s structure using nuclear magnetic resonance (NMR) spectroscopy inside living frog cells.1 The researchers tagged the protein with a beacon, a paramagnetic lanthanide tag, which binds to a cysteine residue on the outside of the protein. ‘The measured effects from the beacons tagged onto the protein give away the positions of the atoms in the protein, in a similar way that a set of satellites can be used to locate the exact position of a GPS receiver,’ Su explains.
13. Structural determination of proteins in living cells by paramagnetic NMR spectroscopy. Pan B. B., Yang F, Ye Y, Wang J. T., Li C, Huber T, Su X. C. Chem. Commun. 2016, 52, 10237-10240.
12. Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer. Ma RS, Li QF, Wang AD, Zhang JH, Liu ZJ, Wu JH, Su XC, Ruan K. Phys. Chem. Chem. Phys. 2016, 18, 13794-13798.
11. Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy. Chen JL, Yang Y, Zhang LL, Liang H, Huber T, Su XC, Otting, G. Phys. Chem. Chem. Phys. 2016, 18, 5850-5859.
10. Site-specific tagging proteins with a rigid, small and stable transition metal chelator, 8-hydroxyquinoline, for paramagnetic NMR analysis. Yang Y, Huang F, Huber T, Su XC. J. Biolmol. NMR 2016, 64, 102-113.