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南开大学元素有机重点实验室

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范志金    教授  博士生导师

Prof. Zhi-Jin Fan (Z.-J. Fan)

Tel: 022-23499464, 022-23504367

E-mail: fanzj@nankai.du.cn

Group Home Page:  http://skleoc.nankai.edu.cn/info/1018/4132.htm

 


EDUCATION

1997-2000    China Agricultural University. Received PhD Degree in July, 2000 (with Prof. Qian Chuanfan).

1991-1994    Beijing Agricultural University. Received MS Degree in June, 1994 (with Associate Prof. Chen Nianchun)

1987-1991    Southwest China Teacher’s University. Received BS Degree in July, 1991.


ACADEMIC CAREER

2014-           PH D Mentor, State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2008-            Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2001-2008    Associate Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2000-2001    Associate Professor, Sichuan Normal University, Sichuan, CHINA.

1994-2000    Lecture, Sichuan Normal University, Sichuan, CHINA.


RESEARCH AREAS

(1) Pesticide Science: Novel Pesticide Development and its MOA

(2) Plant Protection: Plant Pathology and Integrated Disease Management


HONORS AND AWARDS

2020   Award for Second Prize of Tianjin Science and Technology Progress.

2019   Award for Excellent PH D Mentor of PH D dissertation in Nankai University.

2019   Award for The Second Class Prize of Jiangxi Science and Technology Progress Award.

2018   Award for Third Prize of Tianjin Science and Technology Progress.

2012   Award for First Prize of Sichuan Provincial Science and Technology Progress Award.

2006   Award for First Prize of Sichuan Provincial Science and Technology Progress Award.

2005   Award for First Prize of Tianjin Technical Invention.


EDITORAL BOARDS

2019-2023     Member, editorial board of Chinese Journal of Pesticide Science.


SELECTED PUBLICATIONS

  1. Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors. Yu B., Zhao B., Hao Z.S., Chen L., Cao L.X., Guo X.F.*, Zhang N.L., Yang D.Y.*, Zhou S., Tang L.F., Fan Z.J.*. Eur. J. Med. Chem. 2021, 214: 113230.

  2. Design, synthesis and antifungal activity of (E)-3-acyl-5-(methoxyimino)-1,5-dihydrobenzo[e][1,2]oxazepin- 4(3H)-one analogues. Yang D.Y., Wang H.X., Fan Z.J.*, Li Z.M.*, Zhou S., Hao Z.S., Lv Y., Kalinina T. A., Glukhareva T. V.*. Mol. Divers., 2021, 25: 159-169.

  3. Systematic identification of genes associated with plant growth-defense tradeoffs under JA signaling in Arabidopsis. Zhang N.L., Zhao B., Fan Z.J.*, Yang D.Y., Guo X.F., Wu Q.F., Yu B., Zhou S., Wang H.Y.. Planta, 2020, 251 (43): 1-14.

  4. Revealing shared and distinct genes responding to JA and SA signaling in Arabidopsis by meta-analysis. Zhang N.L., Zhou S., Yang D.Y.*, Fan Z.J.*. Front. Plant Sci. 2020, 11: 1-17.

  5. Synthesis, bioactivity and mode of action of 5A5B6C tricyclic spirolactones as novel antiviral lead compounds. Zhu Y.J., Wu Q.F., Fan Z.J.*, Huo J. Q., Zhang J.L., Zhao B.*, Chen L., Qian X.L., Ma D.J., Wang D.W. Pest. Manag. Sci., 2019, 75: 292-301.

  6. Discovery of novel piperidinyl-thiazole derivatives as broad-spectrum fungicidal candidate. Wu Q.F., Zhao B.*, Fan Z.J.*, Guo X.F., Yang D.Y., Zhang N.L., Yu B., Zhou S., Zhao J.B., Chen F. J. Agric. Food Chem., 2019, 67 (5): 1360-1370.

  7. Discovery of novel thiazole carboxamides as antifungal succinate dehydrogenase inhibitors. Guo X.F., Zhao B.*, Fan Z.J.*, Yang D.Y., Zhang N.L., Wu Q.F., Yu B., Zhou S., Tatiana A. Kalinina, Natalia P. Belskaya. J. Agric. Food Chem., 2019, 67 (6): 1647-1655.

  8. Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines. Guo X.F., Yang D.Y.*, Fan Z.J.*, Zhang N.L., Zhao B., Huang C., Wang F.J., Ma R.J., Meng M.*, and Deng Y.C.*. Eur. J. Med. Chem. 2019, 178, 767-781.

  9. Mode of action for a new potential fungicide candidate, 3-(4-Methyl-1,2,3-thiadiazolyl)-6-trichloromethyl- [1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazole by iTRAQ. Zhao B., Wang H.X., Fan Z.J.*, Wu Q. F., Guo X.F., Zhang N.L., Yang D.Y.*, Yu B., Zhou S. Food & Agric. Immunol., 2019, 30 (1): 533-547.

  10. Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones. Zhu Y. J., Huo J. Q., Fan Z. J.*, Wu Q. F., Li X., Zhou S., Xiong L. X., Kalinina T. and Glukhareva T*. Org. Biomol. Chem., 2018, 16 (7): 1163-1166.

  11. Synthesis of novel 3,4-chloroisothiazole-based imidazoles as fungicides and evaluation of their mode of action. Chen L., Zhao B.*, Fan Z.J.*, Liu X.M., Wu Q.F., Li H.P., Wang H.X. J. Agric. Food Chem. 2018, 66 (28): 7319-7327.

  12. A synthetic disaccharide derivative of diphyllin, TAARD, activates human natural killer cells to secrete interferon-gamma via toll-like receptor-mediated NF-κB and STAT3 signaling pathways. Yi L., Chen L.X., Guo X.F., Lu T., Wang H.X., Ji X.T., Zhang J.Y., Ren Y.L., Pan P., Kinghorn A. Douglas, Huang X.H., Wang L.S., Fan Z.J.*, Caligiuri Michael A.* and Yu J.H*. Front. Immunol., 2018, 9: 1509.

  13. Discovery of pyruvate kinase as a novel target of new fungicide candidate 3-(4-methyl-1,2,3-thiadiazolyl)-6- trichloromethyl-[1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazole. Zhao B., Fan S.J., Fan Z.J.*, Wang H.X., Zhang N.L., Guo X.F., Yang D.Y.*, Wu Q.F., Yu B., Zhou S. J. Agric. Food Chem., 2018, 66 (28): 12439-12452.

  14. Discovery of methyl (5Z)-[2-(2,4,5-trioxopyrrolidin-3-ylidene)-4-oxo-1,3-thiazolidin-5-ylidene]acetates as antifungal agents against potato diseases. Konstantin L. Obydennov*, Liliya A. Khamidullina, Alexey N. Galushchinskiy, Svetlana A. Shatunova, Mariya F. Kosterina, Tatiana A. Kalinina, Fan Z.J., Tatiana V. Glukhareva and Yuri Yu. Morzherin. J. Agric. Food Chem., 2018, 66 (24): 6239-6245.

  15. Synthesis and fungicidal activity of monocyclic and fused 1,2,3-triazolium-5-olates. Inna S. Khazhieva, Pavel M. Demkin, Oleg S. Eltsov, Yulia I. Nein,Tatiana A. Kalinina, Fan Z.J.*, Lai Chen, Zhao B.,Tatiana V. Glukhareva*, Yuri Yu. Morzherin*. Chem. Heterocycl. Comp., 2018, 54 (10), 956-963.

  16. Synthesis of 1,2,3-thiadiazole and thiazole based strobilurins as potent fungicide candidates, Chen L., Zhu Y., Fan Z., Guo X., Zhang Z., Xu J., Song Y., Morzherin Y. Y., Belskaya N. P., Bakulev V. A. J. Agric. Food Chem. 2017, 65 (4), 745-751.

  17. Approach to thiazole-containing tetrahydropyridine derivatives via Aza-Rauhut-Currier reaction and their potent fungicidal and insecticidal activity, Zhu Y., Guo X., Fan Z., Chen L., Ma L., Wang H., Wei Y., Xu X., Lin J. and Bakulev V. A. RSC Adv., 2016, 6, 112704-112711.

  18. Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives, Li F., Guo X., Fan Z., Zhang Y., Zong G., Qian X., Ma L., Chen L., Zhu Y., Tatiana K., Morzherin Y. Y., Belskaya N. P. Chin. Chem. Lett. 2015, 26 (10), 1315-1318.

  19. Determination of tiadinil and its metabolite in flue-cured tobacco. Chen X., Zhao K., Fan Z., Mao W., Li J., Ji X., Hua X., Zong G., Li F., J. Chromatogr. Sci. 2014, 52 (7), 624-628.

  20. Novel anthranilic diamide insecticides: design, synthesis, and insecticidal evaluation. Hua X., Mao W., Fan Z.*, Ji X., Li F., Zong G., Song H., Li J., Zhou L., Zhou L., Liang X., Wang G., and Chen X.. Aust. J. Chem. 2014, 67 (10), 1491-1503.

  21. Reactions of β-azolylenamines with sulfonyl azides as an approach to N-unsubstituted 1,2,3-triazoles and ethene-1,2-diamines. Efimov I., Bakulev V., Beliaev N., Beryozkina T., Knippschild U., Leban J., Fan Z., Eltsov O., Slepukhin P., Ezhikova M., Dehaen W.. Eur. J. Org. Chem. 2014, 2014 (17), 3684-3689.

  22. The Natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling. Deng Y., Chu J., Ren Y., Fan Z., Ji X., Bethany M., Yuan S., Tiffany H., Zhang J., Cheema B., Camardo A., Xia Y., Wu L., Wang L., He X., Kinghorn A., Li X., Caligiuri M. and Yu J. J Immunol. 2014, 193 (6), 2994-3002.

  23. Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives. Li Y., Mao W., Fan Z., Li J., Fang Z., Ji X., Hua X., Zong G., Li F., Liu C., Yu J., Chin. Chem. Lett. 2013, 24 (12), 1134-1136.

  24. Preparation of a bifunctional pyrazosulfuron-ethyl imprinted polymer with hydrophilic external layers by reversible addition-fragmentation chain transfer polymerization and its application in the sulfonylurea residue analysis. Yang, M.-X. Zhang Y.-Y., Lin S., Yang X.-L., Fan Z.-J., Yang L.-X., Dong X.-C., Talanta, 2013, 114: 143-151.

  25. Synthesis, bioactivities and structure activity relationship of N-4-methyl-1,2,3-thiadiazole-5-carbonyl-N’- phenyl ureas. Guo D.-D., Wang Z.-W., Fan Z.-J.*, Zhao H., Zhang W., Cheng J.-G., Yang J.-Q., Wu Q.-J., Zhang Y.-J. and Fan Q., Chin. J. Chem. 2012, 30 (10): 2522-2532.

  26. Synthesis and bioactivity of N-tert-butyl-N'-acyl-5-methyl-1,2,3-thiadiazole-4-carbohydrazides. Mao W.-T., Zhao H., Fan Z.-J.*, J X.-T. i, Hu X.-W.a, Tatiana Kalinina, Yu. Y. Morzherin, V. A. Bakulev, Chin. Chem. Lett. 2012, 23 (11): 1233-1236.

  27. Synthesis and insecticidal activity of N-tert-butyl-N, N’-diacylhydrazines containing 1,2,3-thiadiazoles. H. Wang, Z.-K. Yang, Z.-J. Fan*, Q.-J. Wu, Y.-J. Zhang, N. Mi, S.-X. Wang, Z.-C. Zhang, H.-B. Song, F. Liu, J. Agric. Food Chem. 2011, 59 (2): 628-634.

  28. Synthesis, crystal structure and biological activity of two 1,2,3-thiadiazole derivatives. S.-X. Wang, J. Huang, Z.-J. Fan*, H. Wang, Y.-F. Fu, N. Mi, Z.-C. Zhang, H.-B. Song, Belskaya Nataliya P., Bakulev Vasiliy A., J. Chem. Crystallogr. 2011, 41 (9): 1348-1354.

  29. 2-Hydroxypropyl derivatives of 1,2,3‑thiadiazole and 1,2,3-triazole: Synthesis and antifungal activity. Y. Morzherin, Polina E. Prokhorova, Dmitry A. Musikhin, Tatiana V. Glukhareva and Z.-J. Fan, Pure Appl. Chem., 2011, 83 (3): 715-722.


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