EDUCATION 

2003-2009    PhD, Department of Biochemistry and Biomedical Sciences, McMaster University, Canada

1999-2003    BSc, School of Life Sciences, Fudan University, China

1. Mechanistic Studies of Membrane Protein Targets

Focusing on key membrane proteins such as ion channels, we investigate the molecular mechanisms of ligand recognition, 

gating regulation, and species selectivity.

2. Intelligent Design of Small Molecules and Peptides

By integrating structural biology, artificial intelligence, and high-throughput characterization, we carry out the rational design 

and optimization of functional molecules.

3. Creation and Translation of Bioactive Molecules

Combining chemical synthesis, synthetic biology, and functional evaluation platforms, we advance the creation and translational 

application of bioactive molecules for green pesticides and innovative therapeutics.

HONORS AND AWARDS

2025    First Prize, Natural Science Award, the Ministry of Education of China

2025    High-Level Natural Science Innovation Award, Tianjin University

2023    Agricultural Chemistry Innovation Award, Chinese Chemical Society

2020    Excellent Young Scientists Fund, National Natural Science Foundation of China

2017    Young Thousand Talents Program, Tianjin

2017    Excellence in Mentoring Award, American Chemical Society

2015    Michael John Page Award

2013    Michael Smith Fellowship

EDITORAL BOARDS

2022–present    Vice Chair, Youth Editorial Board, Chinese Journal of Pesticide Science

2022–present    Young Editorial Board Member, Advanced Agrochem

2021–present    Editorial Board Member, Cancer Biology & Medicine

SELECTED PUBLICATIONS

ResearcherID: N-5184-2016 | ORCID: 0000-0003-2595-9106

1. Heng Jiang, Ruibo Gao, Huiqin Xu, Cheng Wang, Shuyue Ma, Yishu Gong, Lianyun Lin, Lina Yang, Xiang Li, Ye Liu, Rongcai Lu, Jun-An Ma, Jinbo Xu, Ke Dong, Filip Van Petegem, Zheng Liu*, Shaoying Wu*, Zhiguang Yuchi*, Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design, Nature Communications, 2026, DOI: 10.1038/s41467-026-70190-z

2. Hadiatullah Hadiatullah, Lianyun Lin, Zhiyan Wang, Rajamanikandan Sundarraj, Qing Wang, Xinru Lai, Nagomi Kurebayashi, Takuya Kobayashi, Toshiko Yamazawa, Yu Seby Chen, Wenlan Wang, Hongxia Zhao, Yiqing Yin, Takashi Murayama, Filip Van Petegem, Zhiguang Yuchi*, Crystal structures of ryanodine receptor reveal dantrolene and azumolene interactions guiding inhibitor development, Nature Communications, 2025, 16(1): 10110

3. Xi-Chen Cui, Yan Zheng, Ye Liu, Zhiguang Yuchi*, Ying-Jin Yuan*, AI-driven de novo enzyme design: Strategies, applications, and future prospects. Biotechnology Advances, 2025, 82:108603.

4. Lianyun Lin, Changshi Wang, Wenlan Wang, Heng Jiang, Takashi Murayama, Takuya Kobayashi, Hadiatullah Hadiatullah, Yu Seby Chen, Shunfan Wu, Yiwen Wang, Henryk Korza, Yucheng Gu, Yan Zhang, Jiamu Du, Filip Van Petegem*, Zhiguang Yuchi*, Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance, Nature Communications, 2024, 15(1): 9056

5. Wei Chen, Peng Cao, Yuansheng Liu, Ailing Yu, Dong Wang, Lei Chen, Rajamanikandan Sundarraj, Zhiguang Yuchi, Yong Gong*, Hans Merzendorfer, Qing Yang*, Structural basis for directional chitin biosynthesis. Nature, 2022, 610: 402-408

6. Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang*, Zhiguang Yuchi*, Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy, eLife, 2022, 11(1): 1- 21

7. Yongxu Duan, Yifeng Wei, Meining Xing, Jiayi Liu, Li Jiang, Qiang Lu, Xumei Liu, Yanhong Liu, Ee Lui Ang, Rong-Zhen Liao, Zhiguang Yuchi*, Huimin Zhao*, Yan Zhang*, Anaerobic hydroxyproline degradation involving C–N cleavage by a glycyl radical enzyme, Journal of the American Chemical Society, 2022, 144(22): 9715-9722

8. Qiang Lu, Yifeng Wei, Lianyun Lin, Jiayi Liu, Yongxu Duan, Yaxin Li, Weixiang Zhai, Yangping Liu, Ee Lui Ang, Huimin Zhao*, Zhiguang Yuchi*, Yan Zhang*, The Glycyl Radical Enzyme Arylacetate Decarboxylase from Olsenella scatoligenes. ACS Catalysis, 2021, 11, 9: 5789–5794

9. Ruifang Ma, Omid Haji-Ghassemi, Dan Ma, Heng Jiang, Lianyun Lin, Li Yao, Arthur Samurkas, Yuxin Li, Yiwen Wang, Peng Cao, Shian Wu, Yan Zhang, Takashi Murayama, Bernard Moussian, Filip Van Petegem*, Zhiguang Yuchi*, Structural basis for diamide modulation of ryanodine receptor, Nature Chemical Biology, 2020, 16(1): 1246-1254

10. Jiayi Liu, Yifeng Wei, Lianyun Lin, Lin Teng, Jinyu Yin, Qiang Lu, Jiawei Chen, Yuchun Zheng, Yaxin Li, Runyao Xu, Weixiang Zhai, Yangping Liu, Yanhong Liu, Peng Cao, Ee Lui Ang, Huimin Zhao*, Zhiguang Yuchi*, Yan Zhang*, Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117(27): 15599-15608

11. Meining Xing, Yifeng Wei, Yan Zhou, Jun Zhang, Lianyun Lin, Yiling Hu, Hua, G., Ankanahalli Nanjaraj, Dazhi Liu, Feifei Wang, Cuixia Guo, Yang Tong, Mengya Li, Yanhong Liu, Ee Lui Ang, Huimin Zhao*, Zhiguang Yuchi*, Yan Zhang*, Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria. Nature Communications, 2019, 10(1): 1609.

12. Tong Xu, Zhiguang Yuchi*, Crystal structure of diamondback moth ryanodine receptor Repeat34 domain reveals insect-specific phosphorylation sites. BMC Biology, 2019, 17: 77