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南开大学元素有机重点实验室

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研究队伍

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周传政 教授   

Prof. Chuanzheng Zhou (C.-Z. Zhou)

Tel: 86-22-23497531        

E-mail: chuanzheng.zhou@nankai.edu.cn

 

 

EDUCATION

2004-2010,  Department of Bioogranic Chemistry, Uppsala University, Sweden. Received PhD degree in April, 2010 (with Prof. Jyoti Chattopadhyaya).

2001-2004,  Institute of Elemento-organic Chemistry, Nankai University. Received MS degree in June, 2004 (with Prof. Zhen Xi)

1997-2001,  Department of Chemistry, Nankai University, Tianjin, CHINA. Received BSc Degree in June, 2001.


ACADEMIC CAREER

2014-, Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2010-2014, Postdoctoral associate, Department of Chemistry, Johns Hopkins University, U.S.A. (with Prof. Marc M. Greenberg).


RESEARCH AREAS

(1) Mechanistic study of DNA damage and repair.

(2) Synthesis and modification of nucleic acids, peptides and proteins for therapeutic applications.


     HONORS AND AWARDS              

2024 National Leading Technological Innovation Talents


     SELECTED PUBLICATIONS

(1) Fan, C.; Zhan, X.; Guo, F.; Li, Q.; Lu, K.; Shan, X.; Zhou, Y.; Ren, M.; Greenberg, M. M.; Liu, Y.; Zhou, C., Uridine embedded within DNA is repaired by uracil DNA glycosylase via a mechanism distinct from that of ribonuclease H2. J. Am. Chem. Soc. 2025, 147, 11574-11583.

(2) Ren, M.; Gut, F.; Fan, Y.; Ma, J.; Shan, X.; Yikilmazsoy, A.; Likhodeeva, M.; Hopfner, K.-P.; Zhou, C., Structural basis for human OGG1 processing 8-oxodguo within nucleosome core particles. Nat. Commun. 2024, 15, 9407.

(3) Zhou, Y.; Li, H.; Huang, Y.; Li, J.; Deng, G.; Chen, G.; Xi, Z.; Zhou, C., Suppression of alpha-carbon racemization in peptide synthesis based on a thiol-labile amino protecting group. Nat. Commun. 2023, 14, 5324.

(4) Ren, M.; Greenberg, M. M.; Zhou, C., Participation of histones in DNA damage and repair within nucleosome core particles: Mechanism and applications. Acc. Chem. Res. 2022, 55, 1059-1073.

(5) Li, Q.; Trajkovski, M.; Fan, C.; Chen, J.; Zhou, Y.; Lu, K.; Li, H.; Su, X.; Xi, Z.; Plavec, J.; Zhou, C., 4′-SCF3 labeling constitutes a sensitive 19F NMR probe for characterization of interactions in the minor groove of DNA. Angew. Chem. Int. Ed. 2022, 61, e202201848.

(6) Zhou, Y.; Zhou, C., Designing in vivo active DNAzymes. Nat. Chem. 2021, 13, 299-301.

(7) Wang, H.; Shan, X.; Ren, M.; Shang, M.; Zhou, C., Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis. Nucleic Acids Res. 2021, 49, 12306-12319.

(8) Li, Q.; Chen, J.; Trajkovski, M.; Zhou, Y.; Fan, C.; Lu, K.; Tang, P.; Su, X.; Plavec, J.; Xi, Z.; Zhou, C., 4′-fluorinated RNA: Synthesis, structure, and applications as a sensitive 19F NMR probe of RNA structure and function. J. Am. Chem. Soc. 2020, 142, 4739-4748.