Education   

2012-2017    State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China. Received Ph.D. Degree in July, 2017(with  Prof.Qi-Lin Zhou).

2008-2012    China Pharmaceutical University, Nanjing, China. Received B. Sc. Degree in July, 2012.

Academic Career

2021-            Professor (tenure-track),State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China.

2018-2021    Postdoctoral Associate, Department of Chemistry, The Scripps Research Institute. San Diego, USA. (with Prof. Jin-Quan Yu).

(1)     Organometallic Chemistry

(2)     Transition-Metal Catalysis

(3)     Catalytic Asymmetric Synthesis

Honors & Awards 
2023    Thieme Chemistry Journals Award

2022    National Outstanding Young Talents Program (NSFC)

2021    Nankai University Hundred Young Academic Leaders Program

Selected Publications

1. Jin-Tao Ma^#, Bo-Ying Yao^#, Tianze Zhang, Shi-Hui Cheng, Bin Xuan, Mengchun Ye, Qi-Lin Zhou, Li-Jun Xiao*. Stereoselective Synthesis of Polyketide Motifs via Nickel-Catalyzed Multicomponent Coupling of Aldehydes, Dienes, and Boronic Acids: Reaction Development and Mechanistic Insights. J. Am. Chem. Soc. 2025, 147, 45648−45659.

2. Ye-Wei Huang, Tianze Zhang, Shi-Hui Cheng, Qi-Lin Zhou, Li-Jun Xiao*. Nickel-Catalyzed Enantioselective Direct Addition of Styrenes to Imines Enabled by Chiral Spiro Phosphine Ligands. J. Am. Chem. Soc. 2025, 147, 35675−35683.

3. Shan Jiang, Tianze Zhang, Xiao-Yuan Luo, Shoucheng Dong, Jin-Tao Ma, Li-Jun Xiao*. Ligand-Controlled Regiodivergent Carbosilylation of 1,3-Dienes via Nickel-Catalyzed Three-Component Coupling Reactions. Angew. Chem. Int. Ed. 2025, 64, e202504494.

4. Xian-Ming Liu, Fu Li, Tong-Kun Wang, Ling Dai, Yin Yang, Neng-Quan Jiang, Li-Yuan Xue, Jing-Yuan Liu, Xiao-Song Xue*, Li-Jun Xiao*, Qi-Lin Zhou*. Catalytic Asymmetric Oxidative Coupling between C(sp3)–H Bonds and Carboxylic Acids. J. Am. Chem. Soc. 2025, 147, 627−635.

5. Xu-Ling Pan^#, Wei-Guo Xiao^#, Li-Jun Xiao*, Qi-Lin Zhou, You, Huang*. Phosphine-Catalyzed Enantioselective [2 + 2] Annulations of α-Allyl γ-Benzyl Allenoates via a Transannular Cyclization Approach. Angew. Chem. Int. Ed. 2025, 64, e15642.

6. Kai-Xiang Zhang, Mei-Yu Liu, Bo-Ying Yao, Qi-Lin Zhou, Li-Jun Xiao*. Stereoconvergent and Enantioselective Synthesis of Z-Homoallylic Alcohols via Nickel-Catalyzed Reductive Coupling of Z/E-1,3-Dienes with Aldehydes. J. Am. Chem. Soc. 2024, 146, 22157−22165.

7. Zhi-Hong Chen, Li-Jie Gu, Biao Wang*, Li-Jun Xiao*, Mengchun Ye, Qi-Lin Zhou*. Regioselective and Enantioselective Nickel-Catalyzed Intermolecular Reductive Coupling of Aliphatic Alkenes with Imines. J. Am. Chem. Soc. 2024, 146, 14915–14921.

8. Tianze Zhang, Shan Jiang, Meng-Ying Qian, Qi-Lin Zhou, Li-Jun Xiao*. Ligand-Controlled Regiodivergent Nickel-Catalyzed Hydroaminoalkylation of Unactivated Alkenes. J. Am. Chem. Soc. 2024, 146, 3458−3470.

9. Jin-Tao Ma, Tianze Zhang, Bo-Ying Yao, Li-Jun Xiao*, Qi-Lin Zhou. Diastereodivergent and Enantioselective Synthesis of Homoallylic Alcohols via Nickel-Catalyzed Borylative Coupling of 1,3-Dienes with Aldehydes. J. Am. Chem. Soc.2023, 145, 19195−19201.

10. Ming-Ming Li, Tianze Zhang, Lei Cheng, Wei-Guo Xiao, Jin-Tao Ma, Li-Jun Xiao*, Qi-Lin Zhou*. Ketone α-Alkylation at the More-Hindered Site. Nature Commun. 2023, 14, 3326.

11. Chao Fan, Xin-Yang Lv, Li-Jun Xiao*, Jian-Hua Xie, Qi-Lin Zhou*. Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C−C Bond Cleavage. J. Am. Chem. Soc. 2019, 141, 2889−2893.

12. Lei Cheng, Ming-Ming Li, Li-Jun Xiao*, Jian-Hua Xie, Qi-Lin Zhou*. Nickel(0)-Catalyzed Hydroalkylation of 1,3-Dienes with Simple Ketones. J. Am. Chem. Soc. 2018, 140, 11627–11630.

13. Biao Wang, Xian-Ming Liu, Kai-Xiang Zhang, Wei-Min Feng, Li-Jun Xiao*, Qi-Lin Zhou*. Diastereoselective and Enantioselective Nickel-Catalyzed Reductive Coupling of Imines and Unactivated Alkenes. CCS Chem. 2023, 5, 814–822.

14. Xin-Yang Lv, Chao Fan, Li-Jun Xiao*, Jian-Hua Xie, Qi-Lin Zhou*. Ligand-Enabled Ni-Catalyzed Enantioselective Hydroarylation of Styrenes and 1,3-Dienes with Arylboronic Acids. CCS Chem. 2019, 1, 328−334.

15. Biao Wang^#, Tianze Zhang^#, Li-Jun Xiao*, Qi-Lin Zhou*. Nickel-Catalyzed Intermolecular Reductive Coupling of Styrene and Its Derivatives with Imines Using Methanol as a Reductant. ACS Catal. 2023, 13, 8692−8699.

16. Wei-Guo Xiao, Bin Xuan, Li-Jun Xiao*, Qi-Lin Zhou. Practical Synthesis of Allylic Amines via Nickel-Catalysed Multicomponent Coupling of Alkenes, Aldehydes, and Amides. Chem. Sci. 2023, 14, 8644–8650.

17. Xiao-Ya Sun, Bo-Ying Yao, Bin Xuan, Li-Jun Xiao*, Qi-Lin Zhou*. Recent Advances in Nickel-Catalyzed Asymmetric Hydrofunctionalization of Alkenes. Chem Catalysis 2022, 2, 3140–3162.