EDUCATION
2001-2006 College of Chemistry, Nankai University, Tianjin, China. Received Ph.D. Degree in July, 2006 (with Prof. Yu Liu).
1997-2001 College of Chemistry, Nankai University, Tianjin, China. Received B.S. Degree in July, 2001 (with Prof. Yu Liu).
ACADEMIC CAREER
2013- Professor, College of Chemistry, Nankai University, Tianjin, China.
2014 DAAD Fellowship, Jacobs University Bremen, Germany.
2008 Visiting Professor, Jacobs University Bremen, Host: Prof. Werner M. Nau.
2008-2013 Associate Professor, College of Chemistry, Nankai University, Tianjin, China.
2006-2008 Assistant Professor, College of Chemistry, Nankai University, Tianjin, China.
RESEARCH AREAS
The GUO group takes advantage of molecular recognition and self-assembly of macrocyclic receptors to engineer new smart biomaterials to serve precision/personalized medicine. Ongoing projects within the laboratory include:
(1) Host-guest drug delivery.
(2) Macrocyclic therapeutics.
(3) Supramolecular biosensing/bioimaging.
HONORS AND AWARDS
2022 CCS Lectureship Award for Creative Young Supramolecular Chemists
2019 National Leader in Science and Technology Innovation
2018 Youth Science and Technology Innovation Leader (Ministry of Science and Technology of China)
2018 Tianjin Youth Science and Technology Innovation Leader
2015 Tianjin Natural Science Award (the First-Rank)
2014 Tianjin Excellent Young Science & Technology Talent
2014 Tianjin Program for Support of Top-notch Young Professionals
2013 The 100 Young-Academic-Leader Project of Nankai University
2013 The Science Funds for Excellent Youth (National Natural Science Foundation of China)
EDITORAL BOARDS
2014- Member, Editorial Board of Chinese Chemical Letters.
2023- Member, Editorial Board of Supramolecular Materials.
2025- Member, Young Editorial Board of Responsive Materials.
SELECTED PUBLICATIONS
Xiaoxue Hou, Xin-Yue Hu*, Yang Wang, Huan-Yu Wang, Yu-Chen Pan, Jie Chen, Juan-Juan Li, Ze-Han Wang, Fan Huang*, Jianfeng Liu*, Dong-Sheng Guo*, Single-Molecule Macrocyclic Carrier Overcomes the Direct Transmembrane of Medium-Sized Cargoes, J. Am. Chem. Soc. 2025, 10.1021/jacs.5c04866.
Jia-Hong Tian#, Siyuan Huang#, Ze-Han Wang, Juan-Juan Li, Xianhui Song, Ze-Tao Jiang, Bing-Sen Shi, Ying-Ying Zhao, Hui-Yan Zhang, Ke-Rang Wang, Xin-Yue Hu*, Xinge Zhang*, Dong-Sheng Guo*, Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria, Nat. Commun. 2025, 16, 1016.
Fang-Yuan Chen, Wen-Chao Geng, Meng-Meng Chen, Rong Fu, Han Han, Zhan-Zhan Zhang, Wen-Bo Li, Yuan-Qiu Cheng, Juan-Juan Li, J. Fraser Stoddart*, Kang Cai*, Dong-Sheng Guo*, Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities, Proc. Natl. Acad. Sci. U.S.A. 2025, 122, e2414253122.
Shun-Yu Yao, An-Kang Ying, Ze-Tao Jiang, Yuan-Qiu Cheng, Wen-Chao Geng, Xin-Yue Hu, Kang Cai*, Dong-Sheng Guo*, Single Molecular Nanomedicines Based on Macrocyclic Carrier-drug Conjugates for Concentration-independent Encapsulation and Precise Activation of Drugs, J. Am. Chem. Soc. 2024, 146, 14203-14212.
Wen-Bo Li#, Lin-Lin Xu#, Si-Lei Wang, Ying-Yue Wang, Yu-Chen Pan*, Lin-Qi Shi*, Dong-Sheng Guo*, Co-assembled Nanoparticles toward Multi-target Combinational Therapy of Alzheimer’s Disease by Making Full Use of Molecular Recognition and Self-assembly, Adv. Mater. 2024, 36, 2401918.
Shun-Yu Yao, Yu-Xin Yue, An-Kang Ying, Xin-Yue Hu, Hua-Bin Li, Kang Cai*, Dong-Sheng Guo*, An Antitumor Dual-Responsive Host-Guest Supramolecular Polymer Based on Hypoxia-Cleavable Azocalix[4]arene, Angew. Chem. Int. Ed. 2023, 62, e202213578.
Jia-Hong Tian#, Xin-Yue Hu#, Zong-Ying Hu, Han-Wen Tian, Juan-Juan Li, Yu-Chen Pan, Hua-Bin Li, Dong-Sheng Guo*, A Facile Way to Construct Sensor Array Library via Supramolecular Chemistry for Discriminating Complex Systems, Nat. Commun. 2022, 13, 4293.
Shihui Li, Rong Ma, Xin-Yue Hu, Hua-Bin Li, Wen-Chao Geng, Xianglei Kong, Chao Zhang, Dong-Sheng Guo*, Drug in drug: A Host–Guest Formulation of Azocalixarene with Hydroxychloroquine for Synergistic Anti-inflammation, Adv. Mater. 2022, 34, 2203765.
Yu-Chen Pan, Yu-Xin Yue, Xin-Yue Hu, Hua-Bin Li, and Dong-Sheng Guo*, A Supramolecular Antidote to Macromolecular Toxins Prepared through Co-assembly of Macrocyclic Amphiphiles, Adv. Mater. 2021, 33, 2104310.
Yu-Chen Pan, Andrea Barba-Bon, Han-Wen Tian, Fei Ding, Andreas Hennig, Werner M. Nau, Dong-Sheng Guo*, An Amphiphilic Sulfonatocalix[5]arene as a Novel Activator for Membrane Transport of Lysine-rich Peptides and Proteins, Angew. Chem. Int. Ed. 2021, 60, 1875-1882.
