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南开大学元素有机重点实验室

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实验室介绍

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冯小明  教 授 中国科学院院士      
 

Prof. Xiaoming Feng        

Tel: 028-85418249

Fax: 028-85418249
E-mail: xmfeng@scu.edu.cn



EDUCATION                     

1993-1996
 Chinese Academy of Sciences, Beijing, China. Received Ph.D. degree
in April, 1996 (with Prof. Zhitang Huang and Yaozhong Jiang).
1985-1988
 Department of Chemistry, Lanzhou University, China.Received M.S.
degree in June, 1988 (with Prof. Ziyi Zhang).
1981-1985
 Department of Chemistry, Lanzhou University, China. Received B.S.
degree in June, 1985


ACADEMIC CAREER

2000-Date
 Professor, College of Chemistry, Sichuan University, Chengdu, China
1998-1999
 Postdoctoral fellow, Colorado State University, USA  (with Prof. Yian Shi)
1997-2000
 Professor, Chengdu Institute of Organic Chemistry, CAS, China
1988-1993
 Assistant and associate professor, Southwest Normal University, Chongqing, China



RESEARCH AREAS

Design and synthesis of chiral organocatalysts and ligand-metal complex catalysts, asymmetric catalytic reaction, the synthesis of bioactive compounds

 

HONORS AND AWARDS   

2002
 Award for National Outstanding Young Scientist (National Natural Science Foundation of China)
2005
 Award for the Special Professor of the Chang Jiang Scholars (the Ministry of Education of China)
2009
 Award for Research Achievements in Natural Science of Ministry of Education (First class, China)
2011
 Award for the Top 10 Scientific Achievements of Ministry of Education (China)
2011
 SciFinder Award for Creative Work in Synthetic Organic Chemistry (CCS)
2012
 Award for National Natural Science Awards (Second class, China)
2013
 a Chinese Academy of Sciences Academician
2015
 a fellow of the Royal Society of Chemistry

EDITORAL BOARDS
2012-2015
 Member, Associate Editor of Chinese Chemical Letters
2008-2013
 Member, Editorial Advisory Board of Science China: Chemistry
2011-present
 Member, Academic Advisory Board of Advanced Synthesis & Catalysis
2011-present
 Member, Advisory Board of Current Organic Synthesis
2012-present
 Member, International Advisory Board of Asian Journal of Organic Chemistry
2014-present
 Member, Advisory Board of Synlett /Synthesis



SELECTED PUBLICATIONS 

  1. Yong Xia, Lili Lin, Fenzhen Chang, Yuting Liao, Xiaohua Liu,* and Xiaoming Feng*; Asymmetric Ring Opening/Cyclization/Retro-Mannich Reaction of Cyclopropyl Ketones with Aryl 1,2-Diamines for the Synthesis of Benzimidazole Derivatives, Angew. Chem. Int. Ed. 2016, 55, 12228 -12232.

  2. Haipeng Hu, Yangbin Liu, Lili Lin, Yuheng Zhang, Xiaohua Liu,* and Xiaoming Feng*, Kinetic Resolution of 2H-Azirines by Asymmetric Imine Amidation, Angew. Chem. Int. Ed. 2016, 55, 10098-10101.

  3. Tengfei Kang, Shulin Ge, Lili Lin, Yan Lu, Xiaohua Liu,* and Xiaoming Feng*, A Chiral N,N’-Dioxide-ZnII Complex Catalyzes the Enantioselective [2+2] Cycloaddition of Alkynones with Cyclic Enol Silyl Ether, Angew. Chem. Int. Ed. 2016, 55, 5541-5544.

  4. Jun Li, Lili Lin, Bowen Hu, Xiangjin Lian, Gang Wang, Xiaohua Liu,* and Xiaoming Feng*, Bimetallic Gold(I)/Chiral N,N’-Dioxide Nickel(II) Asymmetric Relay Catalysis: Chemo- and Enantioselective Synthesis of Spiroketals and Spiroaminals, Angew. Chem. Int. Ed. 2016, 55, 6075-6078.

  5.  Yangbin Liu, Xiaohua Liu,* Haipeng Hu, Jing Guo, Yong Xia, Lili Lin, and Xiaoming Feng*, Synergistic Kinetic Resolution and Asymmetric Propargyl Claisen Rearrangement for the Synthesis of Chiral Allenes, Angew. Chem. Int. Ed. 2016, 55, 4054–4058.

  6.  Qian Yao, Yuting Liao, Lili Lin, Xiaobin Lin, Jie Ji, Xiaohua Liu*, Xiaoming Feng*, Efficient Synthesis of Chiral Trisubstituted 1,2-Allenyl Ketones by Catalytic Asymmetric Conjugate Addition of Malonic Esters to Enynes, Angew. Chem. Int. Ed. 2016, 55, 1859–1863.


  8. Yong Xia, Xiaohua Liu*, Haifeng Zheng, Lili Lin, Xiaoming Feng*, A symmetric Synthesis of 2,3-Dihydropyrroles by Ring-Opening/Cyclization of Cyclopropyl Ketones Using Primary Amines; Angew. Chem. Int. Ed. 2015, 54, 227–230.

  9. Yong Xia, Lili Lin, Fenzhen Chang, Xuan Fu, Xiaohua Liu*, Xiaoming Feng*, Asymmetric Ring-Opening of Cyclopropyl Ketones with Thiol, Alcohol, and Carboxylic Acid Nucleophiles Catalyzed by a Chiral N,N’-Dioxide–Scandium(III) Complex, Angew. Chem. Int. Ed. 2015, 54, 13748–13752.

  10.  Haifeng Zheng, Xiaohua Liu*, Chaoran Xu, Yong Xia, Lili Lin, Xiaoming Feng*, Regio- and Enantioselective Aza-Diels–Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609, Angew. Chem. Int. Ed. 2015, 54, 10958–10962.

  11.  Jiannan Zhao, Bing Fang, Weiwei Luo, Xiaoyu Hao, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines, Angew. Chem. Int. Ed. 2015, 54, 241–244.

  12. Wei Li, Fei Tan, Xiaoyu Hao, Gang Wang, Yu Tang, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Intramolecular Homologation of Ketones with α-Diazoesters: Synthesis of Cyclic α-Aryl/Alkyl β-Ketoesters, Angew. Chem. Int. Ed. 2015, 54, 1608–1611.

  13. Xiaohu Zhao, Xiaohua Liu*, Hongjiang Mei, Jing Guo, Lili Lin, Xiaoming Feng*, Asymmetric Dearomatization of Indoles through a Michael/Friedel–Crafts-Type Cascade To Construct Polycyclic Spiroindolines, Angew. Chem. Int. Ed. 2015, 54, 4032–4035.

  14.  Yin Zhu, Xiaohua Liu,* Shunxi Dong, Yuhang Zhou, Wei Li, Lili Lin, Xiaoming Feng*, Asymmetric NH Insertion of Secondary and Primary Anilines under the Catalysis of Palladium and Chiral Guanidine Derivatives, Angew. Chem. Int. Ed. 2014, 53, 1636-1640.

  15.  Yangbin Liu, Haipeng Hu, Haifeng Zheng, Yong Xia, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Nickel(II)-Catalyzed Asymmetric Propargyl and Allyl Claisen Rearrangements to Allenyl- and Allyl-Substituted β-Ketoesters, Angew. Chem. Int. Ed. 2014, 53, 11579-11582.

  16.  Xiaohua Liu, Lili Lin and Xiaoming Feng*, Chiral N,N′-Dioxide Ligands: Synthesis, Coordination Chemistry and Asymmetric Catalysis, Org. Chem. Front., 2014, 1, 298-302.

  17. Jiannan Zhao, Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Lili Lin, Xiaoming Feng*, Asymmetric Synthesis of β-Amino Nitriles through a ScIII-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines, Angew. Chem. Int. Ed. 2013, 52, 3473-3477.

  18. Mingsheng Xie, Xiaohua Liu, Xiaoxia Wu, Yunfei Cai, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric [8+2] Cycloaddition: Synthesis of Cycloheptatriene-Fused Pyrrole Derivative, Angew. Chem. Int. Ed. 2013, 52, 5604-5607.

  19. Jing Guo, Shunxi Dong, Yulong Zhang, Yulong Kuang, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral Scandium(III)-Catalyzed Enantioselective α-Arylation of N-Unprotected 3-Substituted Oxindoles with Diaryliodonium Salts, Angew. Chem. Int. Ed. 2013, 52, 10245-10249.

  20. Wei Li, Xiaohua Liu, Fei Tan, Xiaoyu Hao, Jianfeng Zheng, Lili Lin, Xiaoming Feng*, Catalytic Homologation of α-Ketoesters with α-Diazoesters: Enantioselective Synthesis of Succinate Derivatives with Chiral Quaternary Centers, Angew. Chem. Int. Ed. 2013, 52, 10883-10886.

  21.  Shunxi Dong, Xiaohua Liu*, Yin Zhu, Peng He, Lili Lin, Xiaoming Feng*, Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones, J. Am. Chem. Soc. 2013, 135, 10026-10029.

  22. Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie, Lili Lin, Changwei Hu, Xiaoming Feng*, Completely OH-Selective FeCl3-Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-Tetrahydropyrans, J. Am. Chem. Soc. 2012, 134, 17564-17573.

  23. Lin Zhou, Xiaohua Liu, Jie Ji, Yuheng Zhang, Lili Lin, Xiaoming Feng*, Enantioselective Baeyer−Villiger Oxidation: Desymmetrization of Meso Cyclic Ketones and Kinetic Resolution of Racemic 2‑Arylcyclohexanones, J. Am. Chem. Soc. 2012, 134, 17023-17026. 

  24.  Wei Li, Xiaohua Liu, Xiaoyu Hao, Yunfei Cai, Lili Lin, Xiaoming Feng*, A Catalytic Asymmetric Ring-Expansion Reaction of Isatins and α-Alkyl-α-Diazoesters: Highly Efficient Synthesis of Functionalized 2-Quinolone Derivatives, Angew. Chem. Int. Ed. 2012, 51, 8644-8647.

  25. Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N’-Dioxide–Metal Complexes, Angew. Chem. Int. Ed. 2012, 51, 2776-2779.

  26.  Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral N,N'-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions, Acc. Chem. Res. 2011, 44, 574-587.

  27.  Jun Wang, Xiaohua Liu, Xiaoming Feng*, Asymmetric Strecker Reactions, Chem. Rev. 2011, 111, 6947-6983.

  28. Wei Li, Xiaohua Liu, Xiaoyu Hao, Xiaolei Hu, Yangyang Chu, Weidi Cao, Song Qin, Changwei Hu, Lili Lin, Xiaoming Feng*, New Electrophilic Addition of α-Diazoesters with Ketones for Enantioselective C-N Bond Formation, J. Am. Chem. Soc. 2011, 133, 15268-15271.

  29.  Yunfei Cai, Xiaohua Liu, Jun Jiang, Weiliang Chen, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Chloroamination Reaction of α,β-Unsaturated γ-Keto Esters and Chalcones, J. Am. Chem. Soc. 2011, 133, 5636-5639.

  30. Ke Shen, Xiaohua Liu, Gang Wang, Lili Lin, Xiaoming Feng*, Facile and Efficient Enantioselective Hydroxyamination Reaction: Synthesis of 3-Hydroxyamino-2-Oxindoles Using Nitrosoarenes, Angew. Chem. Int. Ed. 2011, 50, 4684-4688.

  31. Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral N,N'-dioxide-Lanthanide(III) Complex: Metal Directed Reversal of Enantioselectivity, Angew. Chem. Int. Ed. 2011, 50, 4928-4932.

  32. Ke Zheng, Chengkai Yin, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles, Angew. Chem. Int. Ed. 2011, 50, 2573-2577.

  33. Yunfei Cai, Xiaohua Liu, Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Lili Lin, Xiaoming Feng*, Catalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral α-Bromo-β-Amino Ketone Derivatives, Angew. Chem. Int. Ed. 2010, 49, 6160-6164.

  34. Wei Li, Jun Wang, Xiaolei Hu, Ke Shen, Wentao Wang, Yangyang Chu, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Catalytic Asymmetric Roskamp Reaction of α-Alkyl-α-diazoesters with Aromatic Aldehydes: Highly Enantioselective Synthesis of α-Alkyl-β-keto Esters, J. Am. Chem. Soc. 2010, 132, 8532-8533.

  35. Zongrui Hou, Jun Wang, Peng He, Jing Wang, Bo Qin, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Highly Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Copper(I) Complexes of Rigid BINOL Derivatives, Angew. Chem. Int. Ed. 2010, 49, 4763-4766. 

  36. Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Yunfei Cai, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Conjugate Addition of Thioglycolate to Enones Using Mild Lanthanum Catalysis: Lower Catalyst Loading and Remarkably Chiral Amplification, Angew. Chem. Int. Ed. 2010, 49, 4290-4293.

  37. Mingsheng Xie, Xiaohong Chen, Yin Zhu, Bo Gao, Lili Lin, Xiaohua Liu, Xiaoming Feng*. Asymmetric Three-Component Inverse Electron-Demand Aza-Diels-Alder Reaction: Efficient Synthesis of Ring-Fused Tetrahydroquinolines, Angew. Chem. Int. Ed. 2010, 49, 3799-3802.

  38. Shunxi Dong, Xiaohua Liu, Xiaohong Chen, Fang Mei, Yulong Zhang, Bo Gao, Lili Lin, Xiaoming Feng*, Chiral Bisguanidine-Catalyzed Inverse-Electron-Demand Hetero-Diels−Alder Reaction of Chalcones with Azlactones, J. Am. Chem. Soc. 2010, 132, 10650-10651. 

  39. Zhipeng Yu, Xiaohua Liu, Lin Zhou, Lili Lin, Xiaoming Feng*, Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids, Angew. Chem. Int. Ed. 2009, 48, 5195-5198.

  40. Ke Zheng, Jian Shi, Xiaohua Liu, Xiaoming Feng*, Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral N,N′-Dioxide-Nickel(II) Complex: Remarkably Broad Substrate Scope, J. Am. Chem. Soc. 2008, 130, 15770–15771. 

  41. Lijia Wang, Xiaohua Liu, Zhenhua Dong, Xuan Fu, Xiaoming Feng*, Asymmetric Intramolecular Oxa-Michael Addition of Activated α,β-Unsaturated Ketones Catalyzed by a Chiral N,N’-Dioxide Nickel(II) Complex: Highly Enantioselective Synthesis of Flavanones, Angew. Chem., Int. Ed. 2008, 47, 8670-8673.

  42.  Xu Yang, Xin Zhou, Lili Lin, Lu Chang, Xiaohua Liu, Xiaoming Feng*, Highly Enantioselective Direct Michael Addition of Nitroalkanes to Nitroolefins Catalyzed by La(OTf)3/N,N’-Dioxide Complexes, Angew. Chem. Int. Ed. 2008, 47, 7079-7081

  43. Zhipeng Yu, Xiaohua Liu, Zhenhua Dong, Mingsheng Xie, Xiaoming Feng*, An N,N’-Dioxide/In(OTf)3 Catalyst for the Asymmetric Hetero-Diels-Alder Reaction Between Danishefsky's Dienes and Aldehydes: Application in the Total Synthesis of Triketide, Angew. Chem., Int. Ed. 2008, 47, 1308-1311.

  44. Xin Zhou, Xiaohua Liu, Xu Yang, Deju Shang, Junguo Xin, Xiaoming Feng*, Highly Enantioselective Hydrophosphonylation of Aldehydes Catalyzed by Tridentate Schiff Base Aluminum(III) Complexes, Angew. Chem. Int. Ed. 2008, 47, 392-394.

  45. Jie Liu, Zhigang Yang, Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su, Changwei Hu*, Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine, J. Am. Chem. Soc. 2008, 130, 5654-5655.

  46. Jun Wang, Xiaolei Hu, Jun Jiang, Shaohua Gou, Xiao Huang, Xiaohua Liu, Xiaoming Feng*, Asymmetric Activation of tropos 2,2'-Biphenol with Cinchonine Generating a Remarkably Effective Catalyst for the Asymmetric Strecker Reaction of N-Ts Protected Aldimines and Ketoimines, Angew. Chem. Int. Ed. 2007, 46, 8468-8470.

  47. Xiaohua Liu, Bo Qin, Bin He, Xiaoming Feng*, Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt，J. Am. Chem. Soc. 2005, 127, 12224-12225.