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学术报告通知:林雨彤 博士(澳大利亚国立大学 )

来源:元素有机化学国家重点实验室   发布时间:2023/06/28

应元素有机化学国家重点实验室叶萌春教授邀请,澳大利亚国立大学 林雨彤 博士将于6月28日(周三)下午访问重点实验室并做学术报告,具体信息如下:

报告题目:电化学实现的多肽 C-端后期修饰

报 告  人:林雨彤 博士

报告时间:6月28日(周三)下午2:30-3:30

报告地点:六教422会议室

报告摘要:Electrochemistry has attracted increasing attention as a green and practical method in synthetic chemistry, especially in the realm of small molecule synthesis. By stark contrast, the extension of electrosynthesis to peptidic substrates has long been under-employed. The prospect of exploiting the unique interface between organic synthesis and chemical biology has driven us to explore new strategies for the rapid generation of valuable structural analogues of peptide therapeutics. The methodologies developed during my PhD explore the chemo- and regio-selectivity of direct anodic oxidation of peptide C-terminal carboxylates, leveraging electrochemically-generated reactive intermediates, N,O-acetals, as valuable handles for divergent late-stage modifications.

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