Education   

1998-2001    Department of Chemistry, Nankai University, China. Received PhD degree in June, 2001 (with Prof. Yun-Ti Chen)   

1995-1998    Department of Chemistry, Nankai University, China. Received MS degree in June, 2001 (with Prof. Huakuan Lin)

1991-1995    Department of Chemistry, Qufu Normal University, Qufu, China. Received BSc Degree in June, 1991  

(1)     Protein chemistry: methods in protein modifications, protein coupling reactions and biosynthesis

(2)     Methods of biological magnetic resonance for the in-cell applications

(3)     Chemical biology and biochemical analysis

Professional Memberships 

2018-  Member, Editorial board of Scientific Reports

2019-  Member, Editorial Board of Magnetic Resonance Letters

Selected Publications

1. Su XC*, Zhang LY, Zhao LN, Pan BB, Chen BG, Chen JL, Zhai CL, Li B. Efficient protein-protein couplings mediated by small molecules under mild conditions. Angew. Chem. Int. Ed. Engl. 2022 doi: 10.1002/anie.202205597.

2. Chen YT, Li B, Chen JL, Su XC*. Simultaneous discrimination and quantification of enantiomeric amino acids under physiological conditions by chiral ¹⁹F NMR tag. Anal. Chem. 2022, 94, 7853-7860.

3. Wu X, Ma F*, Pan BB, Zhang Y, Zhu L, Deng F, Xu L, Zhao Y, Yin X, Niu H, Su XC*, Shi L*. Tailoring a nanochaperone to regulate α-synuclein assembly. Angew. Chem. Int. Ed. Engl. 2022 doi: 10.1002/anie.202200192.

4. Cui CY, Li B, Cheng D, Li XY, Chen JL, Chen YT, Su XC*. Simultaneous quantification of biothiols and deciphering diverse GSH stability in different live cells by ¹⁹F-tag. Anal. Chem. 2022, 94, 901-908.

5. Chen YT, Li B, Li XY, Chen JL, Cui CY, Hu K, Su XC*. Simultaneous identification and quantification of amino acids in biofluids by reactive ¹⁹F-tags. Chem. Commun. 2021, 13154-13157.

6. Ma B, Chen JL, Cui CY, Yang F, Gong YJ, Su XC.* Rigid, highly reactive and stable DOTA-like tags containing a thiol-specific phenylsulfonyl pyridine moiety for protein modification and NMR analysis. Chem. Eur. J. 2021, 17, 16145-16152.

7. Chen JL, Chen BG, Li B, Yang F, Su XC*. Assessing multiple conformations of lanthanide binding tags for proteins using a sensitive ¹⁹F‐reporter. Chem. Commun. 2021, 4291‐4294.

8. Chen JL, Li B, Li XY, Su XC*. Dynamic exchange of the metal chelating moiety: a key factor in determining the rigidity of protein‐tag conjugates in paramagnetic NMR. J. Phys. Chem. Lett. 2020, 11, 9493‐9500.

9. Yang Y, Chen SN, Yang F, Li XY, Feintuch A, Su XC*, Goldfarb* D. In‐cell destabilization of a homodimeric protein complex detected by DEER spectroscopy. Proc. Natl. Acad. Sci USA 2020, 117, 20566‐20575.

10. Yang Y, Pan BB, Tan X, Yang F, Liu Y*, Su XC*, Goldfarb D*, In‐cell trityl‐trityl distance measurements on proteins. J. Phys. Chem. Lett. 2020, 11, 1141‐1147.

11. 苏循成, 顺磁标记蛋白质在溶液与细胞内研究中的应用.中国科学‐化学 2019, 49, 1318‐1332.

12. Li M, Ning Y, Chen J, Duan X, Song N, Ding D*, Su X*, Yu Z*. Proline isomerization‐regulated tumor microenvironment‐adaptable self‐assembly of peptides for enhanced therapeutic efficacy. Nano. Lett. 2019, 19, 7965‐79768.
    

13. Chen JL, Wang X, Xiao YH, Su XC*. Resonance assignments of lowly populated and unstable enzyme intermediate complex under real‐time conditions. Chembiochem. 2019, 20, 2738‐2742.
    

14. Su XC*, Chen JL. Site‐specific tagging of proteins with paramagnetic ions for determination of protein structures in solution and in cells. Acc. Chem. Res. 2019, 52, 1675‐1686.

15. Pan BB, Yang Y, Liu HZ, Li YH, Su XC*. Coordination of platinum to α‐synuclein inhibits filamentous aggregation in solution. Chembiochem. 2019, 20, 1953‐1958.
    

16. Yang Y, Yang F, Li XY, Su XC*, Goldfarb D*. In‐cell EPR distance measurements on ubiquitin labeled with a rigid PyMTA‐Gd(III) tag. J. Phys. Chem B. 2019, 123, 1050‐1059.

17. Wang X, Chen JL, Otting G, Su XC*. Conversion of an amide to a high‐energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium. Sci. Rep. 2018, 8:16371

18. Yang Y, Yang F, Gong YJ, Bahrenberg T, Feintuch A, Su XC*, Goldfarb D*. High sensitivity in‐cell EPR distance measurements on proteins using an optimized Gd(III) spin label. J. Phys. Chem. Lett. 2018, 9, 6119‐6123

19. Chen JL, Zhao Y, Gong YJ, Pan BB, Wang X, Su XC*. Stable and rigid DTPA‐like paramagnetic tags suitable for in vitro and in situ protein NMR analysis. J. Biomol. NMR 2018, 70, 77‐92.
    

20. Li X, Wu G, Yang Y, Fu S, Liu X, Kang H, Yang X*, Su XC*, Shen Y*. Calmodulin dissociates the STIM1‐Orial complex and STIM1 oligomers. Nat. Commun. 2017, 8, 1042.

21. Yang Y, Gong YJ, Litinov A, Liu HK, Yang F, Su XC*, Goldfarb D*. Generic Tags for Mn(II) and Gd(III) spin labels for distance measurements in proteins. Phys. Chem. Chem. Phys. 2017, 19, 26944‐26956.
    

22. Cao C, Wang S, Cui T, Su XC*, Chou J*. Ion and inhibitor binding of the double‐ring ion selectivity filter of the Mitochondrial calcium uniporter. Proc. Natl. Acad. Sci. USA 2017, 114, E2846‐E2851.

23. Yang Y, Yang F, Gong YJ, Chen Jl., Goldfarb D*, Su XC*. A reactive, rigid Gd(III) labelling tag for in‐cell EPR distance measurements in proteins. Angew. Chem. Int. Ed. Engl. 2017, 56, 2914‐2918.

24. Ma FH, Wang X, Chen JL, Wen X, Sun H*, Su XC*. Deciphering the multisite interactions of a protein and its ligand at atomic resolution by using sensitive paramagnetic effects. Chem. Eur. J. 2017, 23, 926‐934.
    

25. Chen JL, Wang X, Yang F, Cao C, Otting G, Su XC*. 3D Structure determination of an unstable transient enzyme intermediate by paramagnetic NMR spectroscopy. Angew. Chem. Int. Ed. Engl. 2016, 55, 13744‐13748.

26. Pan BB, Yang F, Ye Y, Wang JT, Li C*, Huber T*, Su XC*. Structural determination of proteins in living cells by paramagnetic NMR spectroscopy. Chem. Commun. 2016, 52, 10237‐10240.

27. Pan BB, Yang F, Ye Y, Wang JT, Li C*, Huber T*, Su XC*. Structural determination of proteins in living cells by paramagnetic NMR spectroscopy. Chem. Commun. 2016, 52, 10237‐10240.
    

28. Yang Y, Huang F, Huber T, Su XC*. Site‐specific tagging proteins with a rigid, small and stable transition metal chelator 8‐hydroxyquinoline for paramagnetic NMR analysis. J. Biolmol. NMR 2016, 64, 102‐113.

29. Chen JL, Yang Y, Zhang LL, Liang H, Huber T*, Su XC*, Otting G*. Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy. Phys. Chem. Chem. Phys. 2016, 18, 5850‐5859.
    

30. Yang Y, Wang JT, Pei YY, Su XC*. Site‐specific tagging proteins via a rigid, stable and short thiolether tether for paramagnetic spectroscopic analysis. Chem. Commun. 2015, 51, 2824‐2827.

31. Cao C, Chen JL, Yang Y, Huang F, Otting G, Su XC*. Selective 15N‐labeling of the side‐chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy. J. Biomol. NMR 2014, 59, 251‐261.

32. Ma FH, Chen JL, Li QF, Su XC*. Kinetic assay of Michael addition like thiol‐ene reaction and the insight into protein bioconjugation. Chem. Asian J. 2014, 9, 1808‐1816.

33. Yang Y, Chen JL, Su XC*. PCS in structural biology. Chin. J. Magn. Reson. (杨茵，陈家良，苏循成 *. 蛋白质顺磁标记技术与生物核磁共振中的赝接触位移，波谱学杂志) 2014, 31, 155‐171.

34. Huang F, Pei YY, Zuo HH, Chen JL, Su XC*. Bioconjugation of proteins with a paramagnetic NMR and fluorescent tag. Chem. Eur. J. 2013, 19, 17141‐17149.

35. Wei Z, Yang Y, Li QF, Huang F, Zuo HH, Su XC*. Noncovalent tagging proteins with paramagnetic lanthanide complexes for protein study. Chem. Eur. J. 2013, 19, 5758‐5764.

36. Yang Y, Li QF, Cao C, Huang F, Su XC*. Site‐specific labeling of proteins with a chemically stable, high‐affinity tag for protein study. Chem. Eur. J. 2013, 19, 1097‐1013.

37. Li QF, Yang Y, Maleckis A, Otting G*, Su XC*. Thiol‐ene reaction: a versatile tool in site‐specific labelling of proteins with chemically inert tags for paramagnetic NMR. Chem. Commun. 2012, 48, 2704‐2706.

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