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南开大学元素有机重点实验室

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研究队伍

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王忠文 教授 博士生导师    

Prof. ZhongWen Wang(Z.W. Wang)               

E-mail: wzwrj@nankai.edu.cn

Group Home Page: https://wzwrj.top      


 

Education   

1996    Ph.D. Institute of Elemento-organic Chemistry, Nankai University (with Prof. Zhengming Li)  

1990    B.S. Nankai University (with Prof. Tianlin Liu)  

 

Academic Career                                

2004-         Professor, Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University

2001-2004 Postdoctoral, University of Kentucky, USA (with Prof. Mark S. Meier & Prof. H. Peter Spielmann)

1999-2001 Postdoctoral, Nagoya University, Japan (with Prof. H. Shinohara)

1998-1999 Associate Professor, Institute of Elemento-Organic Chemistry, Nankai University

1996-1998 Assistant Professor, Institute of Elemento-Organic Chemistry, Nankai University


Research Areas

1.    Polycyclic skeletons construction-oriented synthetic methodology.

2.    Natural products synthesis.

3.    Agrochemical lead discovery.



Selected Publications

  1. Yi Cui, Jun Ren, Jiayuan Lv, Zhongwen Wang* “Studies toward the Total Syntheses of Calyciphylline D-Type Daphniphyllum Alkaloids” Org. Lett. 2021, 23, 9189-9193.

  2. Lu Chen, Jun Tian, Yizhou Zhan, Jun Ren, Zhongwen Wang* “Lewis Acid-Catalyzed Intramolecular [3+2] Cross-Cycloaddition of Donor-Acceptor Epoxides with Alkenes for Construction of Oxa-[n.2.1] Skeletons” Chin. J. Chem. 2019, 37, 695-699 (南开百年庆典邀请稿) (As Back Cover).

  3. Pengcai Liu, Yutao Cui, Kang Chen, Xinyue Zhou, Wenyan Pan, Jun Ren, Zhongwen Wang* “Total Syntheses of (−)-Englerins A/B, (+)-Orientalols E/F, and (−)-Oxyphyllol” Org. Lett. 2018, 20, 2517-2521.

  4. Bingxia Sun, Jun Ren, Siyang Xing*, Zhongwen Wang* “Synthesis of (−)-Pyrido[3,4-b]homotropane (PHT) and (±)-PHT via an Intramolecular Cross [3+2] Cycloaddition Strategy” Adv. Synth. Catal. 2018, 360, 1529-1537.

  5. Yizhou Zhan, Tao Liu, Jun Ren, Zhongwen Wang* “Lewis Acid-Catalyzed Intramolecular [3+2] Cross Cycloadditions of Aziridine 2,2-Diesters with Conjugated Dienes for Construction of Aza-[n.2.1] Skeletons” Chem. Eur. J. 2017, 23, 17862-17866 (As Frontispiece).

  6. Chi Zhang, Jun Tian, Jun Ren, Zhongwen Wang* “Intramolecular Parallel [4 + 3] Cycloadditions of Cyclopropane 1,1-Diesters with [3]Dendralenes: Efficient Construction of [5.3.0]decane and Corresponding Polycyclic Skeletons” Chem. Eur. J. 2017, 23, 1231-1236 (As Frontispiece).

  7. Zhenjun Wang, Shuai Chen, Jun Ren, Zhongwen Wang* “Cooperative Photo-/Lewis Acid Catalyzed Tandem Intramolecular [3+2] Cross-Cycloadditions of Cyclopropane 1,1-Diesters with α,β-Unsaturated Carbonyls for Medium-Sized Carbocycles” Org. Lett. 2015, 17, 4184-4187.

  8. Weiwei Ma, Jie Fang, Jun Ren, Zhongwen Wang* “Lewis Acid Catalyzed Formal Intramolecular [3+3] Cross-Cycloaddition of Cyclopropane 1,1-Diesters for Construction of Benzobicyclo[2.2.2]octane Skeletons” Org. Lett. 2015, 17, 4180-4183.

  9. Junhui Zhang, Siyang Xing, Jun Ren, Shende Jiang*, Zhongwen Wang* “Lewis acid catalyzed intramolecular [3+2] cross cycloadditions of cobalt-alkynylcyclopropane 1,1-diesters with carbonyl for construction of medium-sized and polycyclic skeletons” Org. Lett. 2015, 17, 218-221.

  10. Bo Cui, Jun Ren, Zhongwen Wang* “TfOH-catalyzed Formal [3+2] Cycloaddition of Cyclopropane 1,1- Diesters with Nitriles” J. Org. Chem. 2014, 79, 790-796.

  11. Wenju Zhu, Jie Fang, Yong Liu, Jun Ren, Zhongwen Wang* “Lewis Acid Catalyzed Formal Intramolecular [3+2] Cross-Cycloaddition of Cyclopropane 1,1-Diesters with Alkenes: General and Efficient Strategy for Construction of Bridged [n.2.1] Carbocyclic Skeletons” Angew. Chem. Int. Ed. 2013, 52, 2032-2037.

  12. Zhenjun Wang, Jun Ren, Zhongwen Wang* “Lewis Acids Promoted Formal Intramolecular [3+2] Parallel and Cross-Cycloadditions of Cyclopropane 1,1-Diesters with Allenes” Org. Lett. 2013, 15, 5682-5685.

  13. Yu Bai, Weijie Tao, Jun Ren, Zhongwen Wang* “Lewis Acid Catalyzed Intramolecular [4+2] and [3+2] Cross-Cycloaddition of Alkynylcyclopropane Ketones with Carbonyl Compounds and Imines” Angew. Chem. Int. Ed. 2012, 51, 4112-4116.

  14. Zhongwen Wang* “Polar Intramolecular Cross-Cycloadditions of Cyclopropanes toward Natural Product Synthesis” Synlett 2012, 23, 2311-2327 (Account).

  15. Siyang Xing, Yan Li, Zhen Li, Chang Liu, Jun Ren, Zhongwen Wang* “Lewis Acid-Catalyzed Intramolecular Cross [3+2] Cycloaddition of Donor-Acceptor Cyclopropanes with Carbonyls: A General Strategy for Construction of Bridge-Acetal[n.2.1] Skeletons” Angew. Chem. Int. Ed. 2011, 50, 12605-12609.

  16. Linxia Li, Ding Du, Jun Ren, Zhongwen Wang* “N-Heterocyclic Carbene Catalyzed Domino Reactions of Formylcyclopropane 1,1-Diesters: Construction of a 6-5-5 Tricyclic Pyrrolo[1,2-a]indole” Eur. J. Org.Chem. 2011, 614-618.

  17. Siyang Xing, Wenyan Pan, Chang Liu, Jun Ren, Zhongwen Wang* “Efficient Construction of Oxa- and Aza-[n.2.1] Skeletons: Lewis Acid-Catalyzed Intramolecular [3+2] Cycloaddition of Cyclopropane 1,1- Diesters with Carbonyls and Imines” Angew. Chem. Int. Ed. 2010, 49, 3215-3218.

  18. Bao Hu, Siyang Xing, Jun Ren, Zhongwen Wang* “Total Synthesis of (±)-Bruguierol A via an Intramolecular [3+2] Cycloaddition of Cyclopropane 1,1-Diester” Tetrahedron, 2010, 66, 5671-5674.

  19. Bai Yu, Jie Fang, Jun Ren, Zhongwen Wang* “Highly Diastereoselective Gold- or Copper-Catalyzed Formal [4+3] Cycloaddition of 1-(1-Alkynyl) Cyclopropyl Ketones and Nitrones” Chem. Eur. J. 2009, 15, 8975-8978.

  20. Ding Du, Linxia Li, Zhongwen Wang* “N-Heterocyclic Carbene-Catalyzed Domino Ring-Opening/Redox Amidation/Cyclization Reactions of Formylcyclopropane 1,1-Diesters: Direct Construction of a 6-5-6 Tricyclic Hydropyrido[1,2-a]indole Skeleton” J. Org. Chem. 2009, 74, 4379-4382.

  21. Bao Hu, Jianlin Zhu, Siyang Xing, Jie Fang, Ding Du, Zhongwen Wang* “A Highly Site-, Regio-, and Stereoselective Lewis Acid-Catalyzed Formal [3+3] Cycloaddition of Methylenecyclopropane-1,1-Diesters with C,N-Diarylnitrones” Chem. Eur. J. 2009, 15, 324-327.

  22. Yuexia Bai, Jilai Bao, Jun Ren, Zhongwen Wang* “A modified total synthesis of cystothiazole A” Sci. China Ser. B-Chem 2009, 52, 1345-1352.

  23. Bao Hu, Siyang Xing, Zhongwen Wang* “Lewis Acid Catalyzed Ring-Opening Intramolecular Friedel-Crafts Alkylation of Methylenecyclopropane 1,1-Diesters” Org. Lett. 2008, 10, 5481-5484.

  24. Jie Fang, Jun Ren, Zhongwen Wang* “Sc(OTf)3-catalyzed smooth tandem [3+2] cycloaddition/ring opening of donor–acceptor cyclopropane 1,1-diesters with enol silyl ethers” Tetrahedron Lett. 2008, 49, 6659-6662.

  25. Ding Du, Zhongwen Wang* “N-Heterocyclic Carbene-Catalyzed Domino Reactions of Formylcyclopropane 1,1-Diesters: A New Synthesis of Coumarins” Eur. J. Org. Chem. 2008, 4949-4954.