Education   

1989-1994    Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China. Received Ph.D. degree in June, 1994 (with Prof. Zheng-Ming Li).

2005-2009    Department of Chemistry, Central China Normal University, Wuhan, China. Received B. Sc. Degree in June, 1989.

Academic Career

2004-            Professor, Department of Chemistry, Nankai University, Tianjin, CHINA.

2003-2004    Postdoctoral associate, Department of Industrial and Physical Pharmacy, Pharmacy School, Purdue University, USA (with Prof. Shuang Liu).

1999-2003    Postdoctoral associate, Department of Chemistry, Marquette University, USA (with Prof. William A. Donaldson and Prof. Chae S. Yi).

1998-1999    Postdoctoral associate, Department of Chemistry, University of Pretoria, South Africa (with Prof. Tomasz A. Modro).

1994-1998    Lecturer (1994-1996) and Associate Professor (1996-1998), Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China.

(1) Organic synthetic chemistry mainly focused on phosphorus reagents-mediated new reactions and synthetic methods.

(2) Asymmetric catalysis.

(3) Processing chemistry focused on fine chemicals used in the UV curing and electronic materials such as photoresists.

Selected Publications

1. Shixuan Cao, Jiatian Li, Taishan Yan, Jie Han*, Zhengjie He*, UV Light-driven Asymmetric Vinylogous Aldol Reaction of Isatins with 2-Alkylbenzophenones and Enantioselective Synthesis of 3-Hydroxyoxindoles, Org. Chem. Front. 2022, 9, 643–648.

2. Jiayong Zhang, Yuhe Qiu, Biao Zhang, Zhiqiang Huang, Zhengjie He*, P(NMe₂)₃-Mediated Reductive Intramolecular Annulation of Benzoylformates Tethered with a Trisubstituted Alkene Unit and Synthesis of 2,2-Disubstituted 2H-Chromenes, Org. Lett. 2021, 23, 1880-1885.

3. Jiayong Zhang, Jiahang Hao, Zhiqiang Huang, Jie Han, Zhengjie He*, P^III-Mediated Intramolecular Cyclopropanation and Metal-free Synthesis of Cyclopropane-fused Heterocycles, Chem. Commun. 2020, 56, 10251-10254.

4. Hanyuan Li, Bojuan Li, Jianwei Zeng, Changzun Jiang, Zhengjie He*, Enantiopure Chiral Phosphines Bearing a Sulfinyl Group and their Application in Catalytic Enantiodivergent Synthesis of Polysubstituted Pyrrolines, Adv. Synth. Catal. 2020, 362, 2760-2766.

5. Rongfang Liu, Zifeng Qin, Binbin Fan, Ruifeng Li, Rong Zhou*, Zhengjie He*, Phosphine-Catalyzed Chemo- and Diastereoselective [2 + 2 + 2] and [3 + 2] Annulations of γ-Methyl Allenoates with Doubly Activated Olefins: Syntheses of Highly Substituted Cyclohexanes and Cyclopentenes, J. Org. Chem. 2019, 84, 12490-12498.

6. Jinghua Luo, Rongshun Chen, Xia Fan, Junyu Gong, Jie Han*, Zhengjie He*, Catalytic Asymmetric (4 + 1) Annulation of Nitroalkenes with Allylic Acetates: Stereoselective Synthesis of Isoxazoline N-oxides, Org. Biomol. Chem. 2019, 17, 6989-6993.

7. Yiyi Liu, Hengyu Li, Xun Zhou, Zhengjie He*, P(NMe₂)₃-Mediated Reductive (1 + 4) Annulation Reaction of Isatins with Nitroalkenes: An Access to Spirooxindolyl Isoxazoline N-Oxides and Their Corresponding Isoxazolines, J. Org. Chem. 2017, 82, 10997–11007.

8. Hanyuan Li, Jiesi Luo, Bojuan Li, Xizhen Yi, Zhengjie He*, Enantioselective [4 + 1]-Annulation of α,β-Unsaturated Imines with Allylic Carbonates Catalyzed by a Hybrid P-Chiral Phosphine Oxide–Phosphine, Org. Lett. 2017, 19, 5637-5640.

9. Changjiang Yang, Wei Liu, Zijian He, Zhengjie He*, Divergent Reactivity of Nitrocyclopropanes with Huisgen Zwitterions and Facile Syntheses of 3-Alkoxy Pyrazolines and Pyrazoles, Org. Lett. 2016, 18, 4936-4939.

10. Zifeng Qin, Wei Liu, Danyang Wang, and Zhengjie He*, Phosphine-Catalyzed (4 + 1) Annulation of o‑Hydroxyphenyl and o‑Aminophenyl Ketones with Allylic Carbonates: Syntheses and Transformations of 3‑Hydroxy-2,3-Disubstituted Dihydrobenzofurans and Indolines, J. Org. Chem. 2016, 81, 4690-4700.

11. Changjiang Yang, Wei Liu, Zijian He, Zhengjie He*, Divergent reactivity of nitrocyclopropanes with Huisgen zwitterions and facile syntheses of 3-alkoxy pyrazolines and pyrazoles, Org. Lett. 2016, 18, 4936-4939.

12. Changjiang Yang, Xiangyu Chen, Tong Tang, Zhengjie He*, Annulation reaction of 3-acylmethylidene oxindoles with Huisgen zwitterions and its applications in the syntheses of pyrrolo[4,3,2-de]quinolinones and marine alkaloids Ammosamides, Org. Lett. 2016, 18, 1486-1489.

13. Rong Zhou*, Kai Zhang, Yusong Chen, QiangMeng, Yiyi Liu, Ruifeng Li, Zhengjie He*, P(NMe₂)₃-mediated reductive [1+4] annulation of isatins with enones: facile synthesis of spirooxindole-dihydrofurans, Chem. Commun. 2015, 51, 14663-14666.

14. Mei Yang, Tianyi Wang, Shixuan Cao, Zhengjie He*, Phosphine-catalyzed [4+1] annulation of 1,3-(aza)dienes with maleimides: highly efficient construction of azaspiro[4.4]nonenes, Chem. Commun. 2014, 50, 13506-13509.