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南开大学元素有机重点实验室

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实验室介绍

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席 真    教授   

Prof. Zhen Xi (Z. Xi)

E-mail: zhenxi@nankai.edu.cn

 


EDUCATION

1990-1994
 Department of Bioorganic Chemistry, Uppsala University,
Uppsala, Sweden. Received Ph.D. degree in August, 1994
(with Prof. Jyoti C. Chattopadhyaya on the topic of Bioorganic Chemistry).
1985-1988
 Institute of Elemento-Organic Chemistry, Nankai University, Tianjin,
CHINA. Received M. Sc. Degree in June, 1988
(with Prof. Xu-Kun Wang on the topic of Organometallic Chemistry).
1979-1983
 Department of Chemistry, Central China Normal University,
Wuhan, CHINA. Received B. Sc. Degree in June, 1983
(with Prof. Ju-En Shi on the topic of Bioinorganic Chemistry). 

 

ACADEMIC CAREER

1997-2001
 Research Associate, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, U.S.A.
1994-1997
 Postdoc, Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School, U.S.A. (with Professor Irvine H. Goldberg).
1988-1990
 Engineer, Beijing Institute of Chemical Reagents, Beijing, CHINA.
1983-1985
 Assistant Professor, Wuhan University Medical School (Hubei Medical School), Wuhan, CHINA

 


RESEARCH AREAS

(1) Chemical Biology of Nucleic Acids.

(2) Molecular Basis of Pesticide Resistance.

(3) QSAR on Biomolecular Selectivity and Drug Resistance.


HONORS AND AWARDS

2010   Award for Tianjin Mayday Medal 

2009   Award for Tianjin Outstanding Oversea Returnee

2009   Award for Excellent Returnee of National Oversea Chinese Association

2006   Eli Liley Research Excellence Award (China)


ACADEMIC SERVICE

2016-2017  Titular Member, Organic & Biomolecular Chemistry Division, IUPAC.
2016-2017  Chairman, Biomolecular Chemistry Subcommittee, Organic & Biomolecular Chemistry Division, IUPAC.
2014-2015  Associate Member, Organic & Biomolecular Chemistry Division, IUPAC.
2015-2019  Associate Director, Chemical Biology Division, Chinese Chemical Society.
2010-2015  Director, Chemical Biology Division, Chinese Chemical Society.
2006-2010  Associate Director, Chemical Biology Division, Chinese Chemical Society.
2014-2018  Associate Director, Pesticide Science Division, Chinese Chemical Engineering Society.
2013-2017  Member, Supervision Committee of National Natural Science Foundation.
2004-2009  Member of Division of Crop Protection and Agriculture Resources of National Academic Committee
2004-2009  Member of Division of Agriculture of Tianjin Municipal Academic Committee
Member of 11th Evaluation committee of National Natural Science Foundation of China
Member of 12th Evaluation committee of National Natural Science Foundation of China
1st   Expert Committee Member of Overseas Chinese Society of China
8th   Committee Member of Chinese Chemical Society
9th   Committee Member of Chinese Chemical Society
10th Committee Member of Chinese Crop Protection Society

EDITORAL BOARDS
2014-2018   Associate Editor, Editorial Advisory Board of Chinese Journal of Pesticide Science.
2013-Date   Member, Editorial Advisory Board of China Science B.
2012-2015   Member, Editorial Advisory Board of Acta Chimica Sinica.
2012-2015   Member, Editorial Advisory Board of Chinese Chemistry Letter.
2004-Date   Member, Editorial Advisory Board of Chinese Journal of Chemical Process and Engineering.
2005-2014   Member, Editorial Advisory Board of Chinese Science Bulletin(Elsevier).
2004-Date   Member,  Editorial Advisory Board of Chinese Journal of Pesticide Science.

SPECIAL LECTURES

  1. Invited speaker, Frontiers on Wonderful World of Nucleic Acids, Slovenia, 2016.12.14-18.

  2.  Invited speaker, South China Forum for Organic Chemistry, Shenzhen, 2016.11.04-06.

  3. Invited speaker, International Symposium on Ecological Pesticide in Agriculture and Hygiene (EPIAH), Shanghai, 2016.11.01-04.

  4. Invited speaker, Asia 3 Roundtable on Nucleic Acids 2016, Fukuoka, Japan, 2016.09.22-24.

  5. Plenary speaker, BioEcoPesticide Conference, Nanning, 2016.09.07-09.

  6. Plenary speaker, 15th National Conference on Pesticide Research & Education, Guiyang, 2016.08.07-10.

  7. Invited speaker, Advances in Noncanonical Nucleic Acids, Slovenia, 2016.05.14-21.

  8. Invited speaker, NEA & ASIAHORCs Joint Symposium on Chemical Biology, Okinawa, Japan, 2015.11.08-11.

  9. Plenary speaker, 2015 Annual Conference of Chinese Pesticide Industry, Shanghai, 2015.10.27-30.

  10. Invited speaker, Advances in Nucleic Acid Symposium, Poland, 2015.10.14-17.

  11. Invited speaker, Asia 3 Roundtable on Nucleic Acids 2015, Korea, 2015.09.18-21.

  12. Invited speaker, 5th International Conference on Nucleic Acid-Protein Chemical and Structural Biology, Chengdu, 2015.05.02-04 .

  13. Invited Lecture, Central China Normal University, Wuhan, 2015.04.08.

  14. Plenary speaker, 2014 Annual Academic Conference of China Society of Plant Protection, Xiamen, 2014.11.06-07.

  15. Plenary speaker, The 509th Xiangshan Scientific Conference, Beijing, 2014.10.30-31.

  16. Plenary speaker, The CAS Symposium on Advanced Science and Technology, Beijing, 2014.10.28-29.

  17. Co-organizer and speaker, A3RONA (China-Japan-Korea roundtable symposium on nucleic acid), Xiamen, China, 2014.10.16-19.

  18.  Invited speaker, China-Japan Symposium on Chemical Biology, Beijing, 2014.10.10-13.

  19. Plenary speaker, RNAi China 2014, Kunshan, China, 2014.09.25-27.

  20. Co-chairman and speaker, Chemical Biology Division in 29th Chinese Chemical Society Congress, Beijing, 2014.08.04-07.

  21. Invited speaker, The 9th Annual Meeting of Japanese Society for Chemical Biology, Osaka, Japan, 2014.06.11-15.

  22. Invited Lecture, QSAR on Biomolecular Interactions, Konan University, Kobe, Japan. 2014.06.10.

  23. Invited speaker, The 4th International Conference on Nucleic Acid-Protein Chemistry and Structural Biology for Drug Discovery, Chengdu, 2014.06.03-06.

  24. Invited Lecture, QSAR on Biomolecular Interactions, Guizhou University, 2014.05.31.

  25. Invited Lecture, QSAR on Biomolecular Interactions, Macau University of Science and Technology, 2014.05.29.


        SELECTED PUBLICATIONS
 

  1. Chao Wei, Run-Yu Wang, Chang-Yu Zhang, Guo-Ce Xu, Yan-Yan Li, Qiang-Zhe Zhang, Lu-Yuan Li, Long Yi*, Zhen Xi*, Dual-Reactable Fluorescent Probes for Highly Selective and Sensitive Detection of Biological H2S, Chem. Asian J. 2016, 11(9),1376-1381.

  2. Run-Yu Wang, Zhi-Fei Li, Chang-Yu Zhang, Yan-Yan Li, Guo-Ce Xu, Qiang-Zhe Zhang, Lu-Yuan Li, Long Yi*, Zhen Xi*, Fast-Response Turn-on Fluorescent Probes Based on Thiolysis of NBD Amine for H2S Bioimaging,ChemBioChem. 2016,17(10), 962-968.

  3. Jian-Bing Liu, Run-Yu Wang, De-Jun Ma, Chao Wei, Zhen Xi*, Branch-PCR constructed stable shRNA transcription nanoparticles resulted in long-lasting RNAi effect,ChemBioChem. 2016,17(11), 1038-1042.

  4. Jian-Bing Liu, Yan-Yan Li, De-Jun Ma, Di Ouyang, Zhen Xi*, Flexible DNA junction assisted efficient construction of stable gene nanoparticles for gene delivery,Chem. Comm. 2016,52(9), 1953-1956.

  5. Long Yi*, Lv Wei, Run-Yu Wang, Chang-Yu Zhang, Jie Zhang, Tian-Wei Tan*, Zhen Xi*, A Dual-Response Fluorescent Probe Reveals the H2O2-Induced H2S Biogenesis through a Cystathionine beta-Synthase Pathway,Chem. Eur. J. 2015, 21(43), 15167-15172.

  6. Lv Wei, Zhen-Tao Zhu, Yan-Yan Li, Long Yi*, Zhen Xi*, A highly selective and fast-response fluorescent probe for visualization of enzymatic H2S production in vitro and in living cells, Chem. Comm. 2015,51(52), 10463-10466.

  7. Jian-Bing Liu, Run-Yu Wang, De-Jun Ma, Di Ouyang, Zhen Xi*, Efficient construction of stable gene nanoparticles through polymerase chain reaction with flexible branched primers for gene delivery, Chem. Comm. 2015, 51, 9208-9211.

  8. Chang-Yu Zhang, Lv Wei, Chao Wei, Jie Zhang, Run-Yu Wang, Zhen Xi*, Long Yi*, A FRET-ICT dual-quenching fluorescent probe with large off-on response for H2S: synthesis, spectra and bioimaging,Chem. Comm. 2015, 51(35), 7505-7508.

  9. De-Jun Ma, Yong-Hui Xie, Jie Zhang, Di Ouyang, Long Yi*, Zhen Xi*, Self-assembled controllable virus-like nanorods as templates for construction of one-dimensional organic-inorganic nanocomposites,Chem. Comm. 2014,50(98), 15581-15584.

  10. Lv Wei, Long Yi, Fan-Bo Song, Chao Wei, Bai-Fan Wang, Zhen Xi, FRET ratiometric probes reveal the chiral-sensitive cysteine-dependent H2S production and regulation in living cells,Sci. Rep.2014,4, 4521.

  11. Ge-Fei Hao, Ying Tan, Wei-Fang Xu, Run-Jie Cao, Zhen Xi*, Guang-Fu Yang*, Understanding Resistance Mechanism of Protoporphyrinogen Oxidase-Inhibiting Herbicides: Insights from Computational Mutation Scanning and Site-Directed Mutagenesis, J. Agri. Food Chem. 2014,62, 7209-7215.

  12. Chao Wei, Run-Yu Wang, Lv Wei, Long-Huai Cheng, Zhi-Fei Li, Zhen Xi*, Long Yi*, o-Fluorination of Aromatic Azides Yields Improved Azido-Based Fluorescent Probes for Hydrogen Sulfide: Synthesis, Spectra, and Bioimaging, Chem. Asian J. 2014, 9, 3586-3592.

  13. Chao Wei, Qing Zhu, Wei-Wei Liu, Wen-Bin Chen, Zhen Xi*, Long Yi*, NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide,Org. Biomol. Chem. 2014,12(3), 479-85.

  14. Jie Zheng,Lei Zhang,Jun-Bin Zhang, Xiao-Xia Wang,Ke-Qiong Ye,Zhen Xi, Quan Du, Zi-Cai Liang, Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation,FASEB J. 2013,27, 4017-26.

  15. Bai-Fan Wang, Xin Wen, Xiao-Hong Qin, Zhi-Fang Wang, Ying Tan, Yue-Quan Shen*, Zhen Xi*, Quantitative Structural Insight into Human Variegate Porphyria Disease, J. Biol. Chem. 2013, 288(17),11731-11740.

  16. Lv Wei , Li-Qiang Cao, Zhen Xi*, Highly Potent and Stable Capped siRNAs with Picomolar Activity for RNA Interference, Angew. Chem. Int. Ed. 2013, 52, 6501-6503.

  17. Yue-Fang Zhao, Cong-wei Niu, Xin Wen, Zhen Xi*, The minimum activation peptide from ilvH can activate the catalytic subunit of AHAS from different species, ChemBioChem. 2013,14, 746-752.

  18. Ying-Wu He, Cong-Wei Niu, Xin Wen, Zhen Xi*, Biomacromolecular 3D-QSAR to decipher molecular herbicide resistance in acetohydroxyacid synthases, Mol. Informatics. 2013,32, 139-144.

  19. Ge-Fei Hao, Ying Tan, Sheng-Gang Yang, Zhi-Fang Wang, Chang-Fuo Zhan*, Zhen Xi*, Guangfu Yang*, Computational and Experimental insights into the mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase,PLOS ONE. 2013, 8(7), 69198.

  20. Yue-Fang Zhao, Xin Wen, Cong-wei Niu, Zhen Xi*, Arginine 26 and Aspartic Acid 69 of the Regulatory Subunit are Key Residues of Subunits Interaction of Acetohydroxyacid Synthase Isozyme III fromE. coli,ChemBioChem.2012,13,2445-2454.

  21. Jun-Bin Zhang, Jie Zheng, Chang Lu, Quan Du, Zi-Cai Liang, Zhen Xi*, Modification of siRNA passenger strand by 5-nitroindole dramatically reduces its off-target effects,ChemBioChem. 2012,13, 1940-1945.

  22. Shuang Gao, Ruo-Yu Zhang, Zhi-Hong Yu, Zhen Xi*, Antofine Analogues can Inhibit Tobacco Mosaic Virus Assembly through Small-Molecule-RNA Interactions,ChemBioChem. 2012,13, 1622-1627.