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南开大学元素有机重点实验室

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周传政 教授   

Prof. Chuanzheng Zhou (C.-Z. Zhou)

Tel: 86-22-23497531        

E-mail: chuanzheng.zhou@nankai.edu.cn

 

 

Education

2004-2010Department of Bioorganic Chemistry, Uppsala University, SWEDEN. Received PhD degree in April, 2010

 (with Prof. Jyoti Chattopadhyaya).

2001-2004Institute of Elemento-Organic Chemistry, Nankai University, CHINA. Received MS degree in June, 2004

 (with Prof. Zhen Xi).

1997-2001Department of Chemistry, Nankai University, CHINA. Received BSc Degree in June, 2001.


Academic Career

2014-Date Professor (tenure-track), State Key Laboratory of Elemento-organic Chemistry, Nankai University
2010-2014 Postdoctoral Fellow,Johns Hopkins University. Advisor: Professor Marc M. Greenberg

Research Areas

(1) Chemical biology of biological macromolecules (nucleic acids and proteins).

(2) Medical chemistry.


     Honors& Awards              

2019 Young and Middle-aged Leading Personnel in Science and Technology Innovation of Tianjin City.

2009  Chinese Government Award for Outstanding Self-financed Students Studying Abroad.   


     Selected Publications

  1. M. Ren, M. M. Greenberg*, C. Z. Zhou*, Participation of histones in DNA damage and repair within nucleosome core particles: Mechanism and applications. Acc. Chem. Res. 2022, DOI: 10.1021/acs.accounts.2c00041.

  2. H. Wang, X. Shan, M. Ren, M. Shang, C. Z. Zhou*, Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis. Nucleic Acids Res. 2021, 49, 12306-12319.

  3. M. Ren, M. Shang, H. Wang, Z. Xi, C. Z. Zhou*, Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles. Nucleic Acids Res. 2021, 49, 257-268.

  4. H. Wang, C. Zang, M. Ren, M. Shang, Z. Wang, X. Peng, Q. Zhang, X. Wen, Z. Xi, C. Z. Zhou*, Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS). Sci. Rep. 2020, 10, 15385.

  5. Y. Zhang, C. Zang, G. An, M. Shang, Z. Cui, G. Chen, Z. Xi, C. Z. Zhou*, Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones. Nat. Commun. 2020, 11, 1015.

  6. Q. Li, J. Chen, M. Trajkovski, Y. Zhou, C. Fan, K. Lu, P. Tang, X. Su, J. Plavec, Z. Xi, C. Z. Zhou* 4-Fluorinated RNA: Synthesis, structure, and applications as a sensitive 19F NMR probe of RNA structure and function. J. Am. Chem. Soc. 2020, 142, 4739-4748.

  7. C. Zang, H. Wang, T. Li, Y. Zhang, J. Li, M. Shang, J. Du, Z. Xi, C. Z. Zhou*, A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates. Chem. Sci. 2019, 10, 8973-8980.

  8. F. M. Guo, Z. K. Yue, M. Trajkovski, X. P. Zhou, D. Cao, Q. Li, B. F. Wang, X. Wen, J. Plavec*, Q. Peng*, Z. Xi, and C. Z. Zhou*, Effect of ribose conformation on RNA cleavage via internal transesterification. J. Am. Chem. Soc. 2018, 140, 11893-11897.

  9. F. C. Li, Y. Q. Zhang, J. Bai, M. M. Greenberg, Z. Xi, C. Z. Zhou*, 5-Formylcytosine yields DNA-protein crosslinks in nucleosome core particles. J. Am. Chem. Soc. 2017, 139, 10617-10620. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2017, 139, 11629].

  10. Y. Q. Zhang, X. P. Zhou, Y. H. Xie, M. M. Greenberg, Z. Xi, and C. Z. Zhou*, Thiol specific and tracelessly removable bioconjugation via Michael addition to 5‑methylene pyrrolones. J. Am. Chem. Soc. 2017, 139, 6146−6151。