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南开大学元素有机重点实验室

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2F5E2

郭东升  教授  博士生导师

Prof. Dong-Sheng Guo (D.-S. Guo)

Tel: 86-22-23498949

E-mail:dshguo@nankai.edu.cn

Group Home Page: http://www.calixer.cn/

 

 

EDUCATION

2006 College of Chemistry, Nankai University. Received PhD degree in June, 2006 (with Prof. Yu Liu).
2001  College of Chemistry, Nankai University. Received BSc Degree in July, 2001 (with Prof. Yu Liu).

 

ACADEMIC CAREER

2014  DAAD Fellowship, Jacobs University Bremen, Germany
2013- Professor, College of Chemistry, Nankai University
2008-2013 Associate Professor, College of Chemistry, Nankai University
2006-2008  Assistant Professor, College of Chemistry, Nankai University

 

RESEARCH AREAS
The GUO group takes advantage of molecular recognition and self-assembly of calixarenes to engineer new smart biomaterials to achieve precision medicine. Ongoing projects within the laboratory include:

(1)   Inhibition of amyloid fibrillation

(2)   Supramolecular phototheranostics

(3)   Fluorescence sensing for bio-molecules

(4)   Bio-membrane transport activated by calixarenes


HONORS AND AWARDS

2019, National Leader in Science and Technology Innovation

2018, Youth Science and Technology Innovation Leader (Ministry of Science and Technology of China)

2018, Tianjin Youth Science and Technology Innovation Leader

2015, Tianjin Natural Science Award (the First-Rank)

2014, Tianjin Excellent Young Science & Technology Talent

2014, Tianjin Program for Support of Top-notch Young Professionals

2013, The 100 Young-Academic-Leader Project of Nankai University

2013, The Science Funds for Excellent Youth (National Natural Science Foundation of China)


EDITORAL BOARDS

2017-  Member, Editorial Board ofFrontiers in Chemistry.

2014-  Member,Youth Editorial Board ofChinese Chemical Letters.

 

SELECTED PUBLICATIONS

  1. Zhe Xu, Shao-Rui Jia, Wei Wang, Zhi Yuan, Bart Jan Ravoo* and Dong-Sheng Guo*. Peptide Recognition by Co-Assembly of Cyclodextrin and Calixarene Amphiphiles Enables Inhibition of Amyloid Fibrillation. Nat. Chem.,2019,11, 86–93.

  2. Wen-Chao Geng, Shaorui Jia, Zhe Zheng, Zhihao Li, Dan Ding and Dong-Sheng Guo*. A noncovalent fluorescence turn-on strategy for hypoxia imaging. Angew. Chem. Int. Ed.,2019,58, 2377–2381.

  3. Jie Gao, Jun Li, Wen-Chao Geng, Fang-Yuan Chen, Xingchen Duan, Zhe Zheng, Dan Ding* and Dong-Sheng Guo*. Biomarker Displacement Activation: a General Host-Guest Strategy for Targeted Phototheranostics in Vivo. J. Am. Chem. Soc.,2018,140, 4945–4953.

  4. Zhe Zheng, Wen-Chao Geng, Jie Gao, Yu-Ying Wang, Hongwei Sun and Dong-Sheng Guo*. Ultrasensitive and Specific Fluorescence Detection of a Cancer Biomarker via Nanomolar Binding to a Guanidinium-modified Calixarene. Chem. Sci.,2018,9, 2087–2091.

  5. Shu Peng, Andrea Barba-Bon, Yu-Chen Pan, Werner M. Nau,Dong-Sheng Guo,* and Andreas Hennig*. Phosphorylation-Responsive Membrane Transport of Peptides. Angew. Chem. Int. Ed.,2017,56, 15742–15745.

  6. Wen-Chao Geng, Yan-Cen Liu, Zhe Zheng, Dan Ding and Dong-Sheng Guo*. Direct Visualization and Real-time Monitoring of Dissipative Self-assembly by Synchronously Coupled Aggregation-induced Emission. Mater. Chem. Front.,2017,1, 2651–2655.

  7. Shu Peng, Yu-Chen Pan, Yaling Wang, Zhe Xu, Chao Chen, Dan Ding,* Yongjian Wang,* and Dong-Sheng Guo*. Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis. Adv. Sci.,2017, 1700310. (DOI: 10.1002/advs.201700310).

  8. Zhe Xu, Dario Gonzalez-Abradelo, Jun Li, Cristian A. Strassert, Bart Jan Ravoo* and Dong-Sheng Guo*. Supramolecular color-tunable Photoluminescent materials based on a chromophore cascade as security inks with dual encryption. Mater. Chem. Front.,2017,1, 1847–1852.

  9. Wen-Chao Geng, Yan-Cen Liu, Yu-Ying Wang, Zhe Xu, Zhe Zheng, Cheng-Bo Yang and Dong-Sheng Guo*. A self-assembled white-light-emitting system in aqueous medium based on a macrocyclic amphiphile. Chem. Commun.,2017,53, 392–395.

  10. Hai Qian, Yu-Ying Wang,Dong-Sheng Guo and Ivan Aprahamian*. Controlling the Isomerization Rate of an Azo-BFSwitch Using Aggregation. J. Am. Chem. Soc.,2017,139, 1037−1040.

  11. Zhe Xu, Shu Peng, Yu-Ying Wang, Ji-Kai Zhang, Alexandra I. Lazar, and Dong-Sheng Guo*. Broad-Spectrum Tunable Photoluminescent Nanomaterials Constructed from a Modular Light-Harvesting Platform Based on Macrocyclic Amphiphiles. Adv. Mater.,2016,28, 7666–7671.

  12. Yan-Cen Liu, Yu-Ying Wang, Han-Wen Tian, Yu Liu,*Dong-Sheng Guo*. Fluorescent Nanoassemblies between Tetraphenylethenes and Sulfonatocalixarenes: A Systematic Study of Calixarene-Induced Aggregation. Org. Chem. Front.,2016,3, 53–61.

  13. Shu Peng, Jie Gao, Yu Liu* and Dong-Sheng Guo*. Facile fabrication of cross-linked vesicle via “surface clicking” of calixarene-based supraamphiphiles. Chem. Commun.,2015,51, 16557−16560.

  14. Qi Zhang, Yan-Cen Liu, De-Ming Kong,*Dong-Sheng Guo*. Tetraphenylethene Derivatives with Different Numbers of Positively Charged Side Arms have Different Multimeric G-Quadruplex Recognition Specificity. Chem. Eur. J.,2015,21, 13253–13260.

  15. Zhiqiang Zhu, Meiling Hong,Dong-Sheng Guo, Jifu Shi, Zhanliang Tao, and Jun Chen*. All-Solid-State Lithium Organic Battery with Composite Polymer Electrolyte and Pillar[5]quinone Cathode. J. Am. Chem. Soc.,2014,136, 16461−16464.

  16. Dong-Sheng Guo, Yu Liu*. Supramolecular chemistry ofp-sulfonatocalix[n]arenes and its biological applications. Acc. Chem. Rec.,2014,47,1925–1934.

  17. Dong-Sheng Guo, Tian-Xing Zhang, Yi-Xuan Wang, and Yu Liu*. Enzyme-responsive supramolecular polymer by complexation ofbis(p-sulfonatocalixarenes) with suberyl dicholine-based pseudorotaxane. Chem. Commun.,2013,49, 6779–6781.

  18. Dong-Sheng Guo, Kui Wang, Yi-Xuan Wang, Yu Liu*. Cholinesterase-responsive supramolecular vesicle. J. Am. Chem. Soc.,2012,134, 10244–10250.

  19. Dong-Sheng Guo, Yu Liu*. Calixarene-based supramolecular polymerization in solution. Chem. Soc. Rev.,2012,41, 5907–5921.

  20. Dong-Sheng Guo, Vanya D. Uzunova, Xin Su, Yu Liu*, Werner M. Nau*. Operational calixarene-based fluorescent sensing systems for choline and acetylcholine and their application to enzymatic reactions. Chem. Sci.,2011,2, 1722–1734.

 

 

 

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