主要学习工作简历

研究方向及取得的突出成果
主要从事生物活性天然产物及药物合成、涉及C-C键重组的有机合成方法学、不对称有机化学反应研究。建立了一种合成多手性中心、多环结构的新方法。在构筑季碳结构、碳-碳键及碳-杂原子键方面形成了新特点。设计合成了20多个结构复杂并具重要生物活性的分子。其中抗老年痴呆症药物“加兰他敏”合成的专利路线具有产业化价值。此外，发现了40余种新结构倍半萜，建立了仿生合成路线，为萜类抗癌药物的研究提供了一种先导模型。

荣誉与奖励

1. Chen, Z.-M.; Zhang, Z.; Tu, Y.-Q.*; Xu, M.-H.; Zhang, F.-M.; Li, C.-C.; Wang, S.-H. A Mn(iii)/TEMPO-co-Mediated Tandem Azidation-1,2-Carbon Migration Reaction of Allylic Silyl Ethers. Chem. Commun. 2014, 50, 10805-10808.

2. Zhang, F. M.; Tu, Y. Q., Towards the real didemnaketal A: total syntheses of two C-21 stereoisomers of the proposed didemnaketal A. Tetrahedron Lett 2014, 55, 3784-3787.

3. Yang, B. M.; Xiang, K.; Tu, Y. Q.; Zhang, S. H.; Yang, D. T.; Wang, S. H.; Zhang, F. M., Spiro-fused six-membered N-heterocyclic carbene: a new scaffold toward unique properties and activities. Chem Commun 2014, 50, 7163-7165.

4. Wang, S. H.; Li, B. S.; Tu, Y. Q., Catalytic asymmetric semipinacol rearrangements. Chem Commun 2014, 50, 2393-2408.

5. Tian, J. M.; Zhao, X.; Tu, Y. Q.; Gong, W.; Zhang, F. M.; Zhang, S. Y.; Wang, S. H., A Synthetic Approach for Constructing the 3/6/6/5-Fused Tetracyclic Skeleton of Tenuipesine A. Chem-Asian J 2014, 9 , 724-727.

6. Shao, H.; Zhang, X. M.; Wang, S. H.; Zhang, F. M.; Tu, Y. Q.; Yang, C., Propargylic cation-induced intermolecular electrophilic addition-semipinacol rearrangement. Chem Commun 2014, 50, 5691-5694.

7. Hou, S. H.; Tu, Y. Q.; Liu, L.; Zhang, F. M.; Wang, S. H.; Zhang, X. M., Divergent and Efficient Syntheses of the Lycopodium Alkaloids (-)-Lycojaponicumin C, (-)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Angew. Chem. Int. Ed. 2013, 52, 11373-11376.

8. Chen, Z. M.; Bai, W.; Wang, S. H.; Yang, B. M.; Tu, Y. Q.; Zhang, F. M., Copper-Catalyzed Tandem Trifluoromethylation/ Semipinacol Rearrangement of Allylic Alcohols.Angew. Chem. Int. Ed. 2013, 52, 9781-9785;.

9. Peng, J. B.; Qi, Y.; Ma, A. J.; Tu, Y. Q.; Zhang, F. M.; Wang, S. H.; Zhang, S. Y., Cascade Oxidative Dearomatization/Semipinacol Rearrangement: An Approach to 2-Spirocyclo-3-oxindole Derivatives. Chem-Asian J 2013, 8, 883-887.

10. Li, B. S.; Liu, W. X.; Zhang, Q. W.; Wang, S. H.; Zhang, F. M.; Zhang, S. Y.; Tu, Y. Q.; Cao, X. P., Direct Syntheses of Spiro- and Fused-Hydrofurans by a Tunable Tandem Semipinacol Rearrangement/Oxa-Michael Addition Protocol. Chem-Eur J 2013, 19, 5246-5249.

11. Zhang, Q. W.; Zhang, X. B.; Li, B. S.; Xiang, K.; Zhang, F. M.; Wang, S. H.; Tu, Y. Q., Catalytic intermolecular carbon electrophile induced semipinacol rearrangement.Chem Commun 2013, 49 , 1648-1650.

12. Peng, L.; Zhang, F. M.; Yang, B. M.; Zhang, X. B.; Liu, W. X.; Zhang, S. Y.; Tu, Y. Q., Toward the natural didemnaketal A: total synthesis of the isomer of didemnaketal A.Tetrahedron Lett 2013, 54 (48), 6514-6516.

13. Zhang, F. M.; Peng, L.; Li, H.; Ma, A. J.; Peng, J. B.; Guo, J. J.; Yang, D. T.; Hou, S. H.; Tu, Y. Q.; Kitching, W., Total Synthesis of the Nominal Didemnaketal A.Angew. Chem. Int. Ed. 2012, 51, 10846-10850.

14. Jiao, Z. W.; Zhang, S. Y.; He, C.; Tu, Y. Q.; Wang, S. H.; Zhang, F. M.; Zhang, Y. Q.; Li, H., Organocatalytic Asymmetric Direct Csp3-H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers. Angew. Chem. Int. Ed. 2012, 51, 8811-8815.

15. Li, B. S.; Yang, B. M.; Wang, S. H.; Zhang, Y. Q.; Cao, X. P.; Tu, Y. Q., Copper(I)-catalyzed intramolecular [2+2] cycloaddition of 1,6-enyne-derived ketenimine: an efficient construction of strained and bridged 7-substituted-3-heterobicyclo[3.1.1]heptan-6-one. Chem Sci 2012, 3 (6), 1975-1979.