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元素有机化学国家重点实验室

National Distinguished Young Scholars

Faculty

谢建华  研究员  杰青

Prof. Jian-Hua Xie(J.-H. Xie)

Tel: 86-22-23508049

E-mail: jhxie@nankai.edu.cn

Group Home Page:http://zhou.nankai.edu.cn  

EDUCATION

2000-2003             The Research Institute of Elemento-organic Chemistry, Tianjin,
          CHINA.
Received Ph.D. Degree in June, 2003. 
          (with Prof. Q.-L. 
Zhou)

1994-1997             The Research Institute of Elemento-organic Chemistry, Tianjin,
          CHINA.
Received M. Sc. Degree in June, 1997. 
          (with Prof. T.-L. 
Liu)

1990-1992              Department of Chemistry, Sichuan Teachers College,Nanchong,
          CHINA.
Received B. Sc. Degree in June, 1992.

1988-1990              Department of Chemistry, Neijiang Teachers College,Neijian,
          CHINA.




ACADEMIC CAREER

2008-                       Associate Professor and Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2007-2008               Postdoctoral Fellow, Department of Chemistry and BiochemistryUniversity of Maryland, U.S.A. 
           (with Prof.
Micheal P. Doyle).

2003-2007               Assistant and Associate Professor, The Research Institute of Elemento-organic Chemistry,Tianjin, CHINA.

1997-2000               Engineer, Chengdu Di’ao Pharmaceutical company, ChengduCHINA.


RESEARCH AREAS

(1)  Homogeneous catalysisespecially the development of new chiral ligands, catalysts and catalytic systems for asymmetric reactions.

(2)  Natural products synthesisespecially the development of new asymmetric catalysis methods for the synthesis of biologically active  natural products and structural analogues.

 

HONORS AND AWARDS

2013              Award for National Outstanding Young Scientist (National Natural Science Foundation of China)

2012              Thieme Chemistry Journals Award

2008              New Century Excellent Talents Project (Ministry of Education, China)

2007              Tianjin Natural Science Award (The First-Rank)

 

SELECTED PUBLICATIONS

  1. Yang Liu, Li-Jie Cheng, Hai-Tao YueWen CheJian-Hua Xie*, Qi-Lin Zhou,Divergent enantioselective synthesis of hapalindole-type alkaloids using catalytic asymmetric hydrogenation of a ketone to construct the chiral core structure,Chem. Sci. 2016,7, 4725-4729.
  2. Han LinLi-Jun XiaoMin-Jie ZhouHong-Ming YuJian-Hua Xie*,Qi-Lin Zhou*,Enantioselective approach to (−)-hamigeran B and (−)-4-bromohamigeran B via catalytic asymmetric hydrogenation of racemic ketone to assemble the chiral coreframework,Org. Lett. 2016,18, 1434-1437.
  3. Deng-Hui BaoHui-Ling Wu, Chao-Lun Liu, Jian-Hua Xie*, Qi-Lin Zhou*, Development of chiral spiro P-N-S ligands for iridium-catalyzed asymmetric hydrogenation of α-alkyl-β-ketoestersAngew. Chem. Int. Ed. 2015, 54,8791-8794.
  4. Xiao-Hui. Yang, Ke Wang, Shou-Fei Zhu, Jian-Hua Xie*Qi-Lin. Zhou*, Remote ester group leads to efficient kinetic resolution ofracemic aliphatic alcohols via asymmetric hydrogenation, J. Am. Chem. Soc2014, 136, 17426-17429.
  5. Chong Liu, Jian-Hua Xie*, Ya-Li Li, Ji-Qiang Chen, Qi-Lin Zhou*, Asymmetric hydrogenation of α,α¢-disubstituted cycloketonesthrough dynamic kinetic resolution: An efficient construction of chiral diols with three contiguous stereocentersAngew. Chem. Int. Ed201352, 593-596.
  6. Xiao-Hui Yang, Jian-Hua Xie*, Wei-Peng Liu, Qi-Lin Zhou*Catalytic asymmetric hydrogenation of δ-ketoesters: Highly efficient approach to chiral 1,5-diols, Angew. Chem. Int. Ed201352, 7833-7836.
  7. Li-Jie Cheng, Jian-Hua Xie*, Yong Chen, Li-Xin Wang, Qi-Lin Zhou*Enantioselective total synthesis of Δ8-THC and Δ9-THC via catalytic asymmetric hydrogenation and SNAr cyclizationOrg. Lett201315, 764-767.
  8. Gang Li, Jian-Hua Xie*, Jing HouShou-Fei Zhu, Qi-Lin Zhou*Catalytic asymmetric hydrogenation of α-arylcyclohexanones and total synthesis of (−)-α-lycoraneAdv. Synth. Catal. 2013355, 1597-1604.
  9. Jian-Hua Xie*, Xiao-Yan Liu, Xiao-Hui Yang, Jian-Bo Xie, Li-Xin Wang, Qi-Lin Zhou*Chiral iridium catalysts bearing spiropyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of b-aryl-β-ketoestersAngew. Chem. Int. Ed201251, 201-203.
  10. Qian-Qian Zhang, Jian-Hua Xie*, Xiao-Hui Yang, Jian-Bo XieQi-Lin Zhou*Iridium-catalyzed asymmetric hydrogenation of α-substituted α-unsaturated acyclic ketonesEnatioselective total synthesis of (–)-mesemberOrg. Lett201214, 6158-6161.
  11. Ji-Qiang Chen, Jian-Hua Xie*, Deng-HuiBaoSheng. Liu, Qi-Lin Zhou*Total synthesis of (–)-galanthamine and (–)-lycoraminevia catalytic asymmetric hydrogenation and intromolecular reductive Heck cyclizationOrg. Lett201214, 2714-2717.
  12. Jian-Hua Xie*, Lu-Chuan Guo, Xiao-Hui Yang, Li-Xin Wang, Qi-Lin Zhou*, Enantioselective synthesis of 2,6-cis-disubstitutedtetrahydropyrans via a tandem catalytic asymmetric hydrogenation/oxa-Michael cyclization: An efficient approach to (–)-centrolobineOrg. Lett201214, 4758-4761.
  13. Li-Jie Cheng, Jian-Hua Xie*, Li-Xin Wang, Qi-Lin Zhou*, Enantioselective synthesis of (–)-CP-55940 via ruthenium catalyzed asymmetric hydrogenation, Adv. SynthCatal2012354, 1105-1113.
  14. Jian-Hua Xie*, Xiao-Yan Liu, Jian-Bo XieLi-Xin Wang, Qi-Lin Zhou*, An additional coordination group leads to extremely efficient chiral iridium catalysts for asymmetric hydrogenation of ketonesAngew. Chem. Int. Ed201150, 7329-7332.
  15. XieJian-Bo; J.-H. Xie*, Xiao-Yan Liu, Qian-Qian Zhang, Qi-Lin Zhou*,Chiral iridium spiro aminophosphine complexes: asymmetric hydrogenation of simple ketones, structure and plausible mechanism, Chem. Asian J20116, 899-908.
  16. XieJian-Bo; Jian-Hua Xie*, Xiao-Yan Liu, Wei-Ling Kong, Sheng Li, Qi-Lin Zhou*, Highly enantioselective hydrogenation of α-arylmethylene cycloalkanones catalyzed by iridium complexes of chiral spiro aminophosphine ligandsJ. Am. Chem. Soc2010,132, 4538-4539.