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元素有机化学国家重点实验室

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【Pingping Tang's Group】Direct Dehydroxytrifluoromethoxylation of Alcohols

Release unit:SKLEOC   Release time:2017/12/27    Browse times:56



The first example of a direct dehydroxytrifluoromethoxylation of alcohols has been developed. This method generated an alkyl fluoroformate in situ from alcohols and followed nucleophilic trifluoromethoxylation with trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxylation reagent. This reaction is operationally simple, scalable and proceeds under mild reaction conditions, and provides access to a wide range of trifluoromethyl ethers from alcohols. In addition, this method is suitable for the late-stage trifluoromethoxylation of complex small molecules.

Read more: http://onlinelibrary.wiley.com/doi/10.1002/anie.201711050/epdf.