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元素有机化学国家重点实验室(南开大学)

Tenure制研究员

研究队伍

轩维民  特聘研究员  博士生导师

Prof. Weimin Xuan

E-mail: weimin_xuan@163.com


EDUCATION

 2009-2013 Department of Chemistry, University of New Mexico, New Mexico, USA.
Received Ph.D. degree in July 2013 (with Prof. Wei Wang)  
 2003-2007

School of Pharmaceutical Science, Tianjin University, Tianjin, China.
Received B. Sc. Degree in July, 2007


 

ACADEMIC CAREER

2017.11-   Professor(tenure-track),Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.
2013-2017  Research Associate, the Scripps Research Institute, (with Prof. Peter G. Schultz)
2007-2009  Administrative staff, Department of Sci. & Tech. Tianjin University


 


RESEARCH AREAS

1    Protein modification with genetically encoded unnatural amino acids;

2)     Genetically encoded fluorescent or bioluminescent probes;

3)     Protein-based drugs;

4)     Development of new biotechnology


HONORS and AWARDS

2011, the Second-Place Award in the Graduate Poster Competition, the First Annual Research Symposium, Department of Chemistry & Chemical Biology, University of New Mexico.

2005-2006, an honor of Excellent Student Leadership in the city of Tianjin.

2003-2005, an honor for Three A’s student in two consecutive years.

2004. 10, an honor of G. Stork Scholarship.


SELECTED PUBLICATIONS

  1. Xuan, W.;§Yao, A.;§Schultz PG. Genetically encoded fluorescent probe for detecting sirtuins in living cells. J. Am. Chem. Soc., 2017, 139 (36), pp12350–12353.
  2. Xuan, W.; Schultz, PG. A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids. Angew. Chem. Int. Ed. 2017, 56, 9170-9173.
  3. Xuan, W.; Shao, S.; Schultz, PG. Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Aryl Carbamate Side Chains. Angew. Chem. Int. Ed. (hot paper) 2017, 56, 5096–5100.
  4. Xuan, W.; Li, J.; Luo, X.; Schultz, PG. Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins. Angew. Chem. Int. Ed. 2016, 55, 10065-10068.
  5. Xuan, W.;§Pan, R.§(equal contribution); Wei Y.; Cao, Y.; Li, H.; Liang, FS.; Liu, K.; Wang, W. Reaction-based “off-on” Fluorescent Probe Enabling Detection of Endogenous Labile Fe2+ and Imaging of Zn2+ - induced Fe2+ Flux in Living Cells and Elevated Fe2+ in Ischemic Stroke. Bioconjugate Chem., 2016, 27, 302−308.
  6. Xiao, H.;§Xuan, W.§(equal contribution); Shao, S.; Liu, T.; Schultz, P. G. Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones. ACS Chem. Biol. 2015, 10, 1599−1603. 
  7. Xuan, W.; Cao, Y; Zhou, J.; Wang, W. A FRET-based ratiometric fluorescent and colorimetric probe for facile detection of organophosphonate nerve agent mimic DCP. Chem. Commun., 2013, 49, 10474—10476.
  8. Xuan, W.; Pan, R.; Cao, Y.; Liu, K.; Wang, W.A fluorescent probe capable of detecting H2S at submicromolar concentrations in cells. Chem. Commun., 2012, 48, 10669-10671.
  9. Xuan, W.; Chen, C.; Cao. Y.; He, W.; Jiang, W.; Liu, K.; Wang, W. Rational design of a ratiometric fluorescent probe with a large emission shift for the facile detection of Hg2+. Chem. Commun., 2012, 48, 7292–7294.
  10. Xuan, W.; Sheng, C.; Cao, Y.; He, W.; Wang, W. Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems (highlights). Angew. Chem. Int. Ed. 2012, 51, 2282 – 2284.
5th EOC Symposium