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元素有机化学国家重点实验室(南开大学)

Tenure制研究员

研究队伍

周传政   特聘研究员 博士生导师

Prof. Chuanzheng Zhou (C.-Z. Zhou)

Tel: 86-22-23497531

E-mail: chuanzheng.zhou@nankai.edu.cn

 

EDUCATION

2004-2010      Ph.D. in Bioorganic Chemistry, Uppsala University 
                       
Advisor: Professor Jyoti Chattopadhyaya.

2001-2004      M.S. in Organic Chemistry, Nankai University 
                       
Advisor: Professor Zhen Xi.

1997-2001      B.S. in Chemistry, Nankai University.



                       



ACADEMIC CAREER
2014-Date
Professor (tenure-track), State Key Laboratory of Elemento-organic Chemistry, Nankai University
2010-2014
Postdoctoral FellowJohns Hopkins University. Advisor: Professor Marc M. Greenberg

RESEARCH AREAS

Chemical biology , Medical chemistry, Physical organic chemistry

     AWARDS AND HONORS

      2015  Thousand Young Talents, Chinese Government (国家青年千人)

      2012  Travel Award of 244th ACS National Meeting, PhiladelphiaPA.

2009  Chinese Government Award for Outstanding Self-financed Students Studying Abroad (国家优秀自费留学生奖学金)

      2007  Gordon Research Conference, Chair's Refund, NewportRI.


     Selected Publications

1.    Weng, L.; Zhou, C.; Greenberg, M.M. “Probing Interactions Between Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis” ACS Chem. Biol. 201510, 620-630. [Featured in Chemical Research in Toxicology Spotlights: Chem. Res. Toxicol201528, 2−3]

2.    Zhou, C. and Greenberg, M. M.  “DNA Damage by Histone Radicals in Nucleosome Core Particles” J. Am. Chem. Soc. 2014136, 6562-6565.

3.    Zhou, C. and Chattopadhyaya J. (2013) “Challenges in the Chemistry of Small Interfering RNA as Potential Therapeutics to Inhibit Cellular mRNA Expression” In Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering; Reedijk, J. (Ed.) Elsevier: Waltham, MA; doi: 10.1016/B978-0-12-409547-2.05337-3.

4.   Zhou, C., Sczepanski, J. T. and Greenberg, M. M. “Histone modification vis rapid cleavage of C4’-oxidized abasic sites in nucleosome core particles” J. Am. Chem. Soc2013, 135, 5274-5277. [Featured in JACSSpotlightsJ. Am. Chem. Soc. 2013135, 5933]

5.  Sczepanski, J. T., Zhou, C. and Greenberg, M. M. “Nucleosome core particle catalyzed strand scission at abasic sties” Biochemistry201352, 2157–2164.

6.    Zhou, C, Sczepanski, J. T. and Greenberg, M. M. “Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles” J. Am. Chem. Soc2012134, 16734-16741.

7.    Zhou, C and Greenberg, M. M. “Histone catalyzed cleavage of nucleosomal DNA containing 2-deoxyrionolactone” J. Am. Chem. Soc. 2012134, 80908093. [Featured in JACS SpotlightsJ. Am. Chem. Soc.2012134, 9021]

8.     Zhou, C. and Chattopadhyaya, J. “Intramolecular Free-Radical Cyclization Reactions on Pentose-Sugars for Synthesis of carba-LNA and carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics” Chem. Rev. 2012112, 3808-3832.

9.    Zhou, C. and Chattopadhyaya, J.  “Why carba-LNA Modified Oligonucleotides Show Considerably Improved 3′-Exonuclease Stability Compared to that of the LNA Modified or the Native Counterparts : A Michaelis-Menten Kinetic Analysis” J. Org. Chem2010752341-2349.

10.  Zhou, C. and Chattopadhyaya, J.  “The synthesis of therapeutic locked nucleos(t)ides” Curr. Opin. Drug Discov. Devel. 200912, 876-898.

11.   Zhou, C.; Plashkevych, O.; Chattopadhyaya, J. “Double Sugar and Phosphate Backbone-constrained Nucleotides: Synthesis, Structure, Stability and Their Incorporation into Oligodeoxynucleotides” J. Org. Chem.200974, 3248-3265. [JOC Featured Article]

12.   Zhou, C.Liu, Y.; Andaloussi, M.; Badgujar, N.; Plashkevych, O.; Chattopadhyaya, J. “Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′, 4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties” J. Org. Chem. 200974, 118-134.