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元素有机化学国家重点实验室(南开大学)

骨干研究人员

研究队伍

陈弓   教授  青年长江学者   杰青

Prof. Gong Chen (G. Chen)

E-mail: gongchen@nankai.edu.cn


EDUCATION


1998     BS, Nanjing University
2004     PhD, Columbia University, USA


ACADEMIC CAREER

2015- 
Professor, the State Key Laboratory of Elemento-organic Chemistry, Nankai University
2014-2015 
Associate Professor, Department of Chemistry, The Pennsylvania State University, USA
2008-2014
Assistant Professor, Department of Chemistry, The Pennsylvania State University, USA
2005-2008
Postdoctoral, Memorial Sloan-Kettering Cancer Center, USA

REEARCH AREAS

Organometallic chemistry,synthetic methodology, total synthesis, chemical biology of complex peptides and oligosaccharides, medicinal chemistry

HONORS AND AWARDS

2015   青年长江学者 
2014   中美化学与化学生物学教授联合会杰出青年教授奖 
2013   美国安进青年研究员奖 
2011   Thieme化学杂志奖 
2011   美国自然科学基金会事业奖


SELECTED PUBLICATIONS

  1.  Synthesis of b-alkynyl a-amino acids via palladium-catalyzed alkynylation of unactivated C(sp3)-H bonds,  B. Wang, G. He, S.-Y. Zhang, W. A. Nack, and G. Chen, Sci. China Chem2015. 58, 1345-1348.
  2. Palladium-catalyzed trifluoroacetate-promoted mono-arylation of β methyl group of alanine at room temperature: synthesis of β-arylated α-amino acids through sequential C-H functionalization, B. Wang, W. A. Nack, G. He, S.-Y. Zhang, and G. Chen, Chem. Sci. 20145, 3952-3957.
  3.  Stereoselective synthesis of b-alkylated a-amino acids via palladium-catalyzed alkylation of methylene C(sp3)-H bonds, S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen, J. Am. Chem. Soc. 2013135,12135-12141.
  4. Palladium-catalyzed picolinamide-directed alkylation of unactivated C(sp3)-H bonds with alkyl iodides, S.-Y. Zhang, G. He, W. A. Nack, Y.-S. Zhao, Q. Li, and G. Chen, J. Am. Chem. Soc. 2013135, 2124-2127.
  5.   Anticancer PAD inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity, Y.-J. Wang, P. Li, S. Wang, J. Hu, M. Fisher, K. Oshaben, J. Wu, N. Zhao, D. Wang, G. Chen, Y.-M. Wang, J. Biol. Chem. 2012287, 25941-25953.
  6. Efficient ether synthesis via palladium-catalyzed picolinamide-directed alkoxylation of unactivated C(sp3) and C(sp2)-H bonds at remote positions, S.-Y. Zhang, G. He, Y.-S. Zhao, and G. Chen, J. Am. Chem. Soc2012134, 7313-7316.
  7. Chemical synthesis of N-linked glycans carrying both mannose-6-phosphate and GlcNAc-mannose-6-phosphate motifs, Y.-P. Liu, and G. Chen, J. Org. Chem. 201176, 8682-8689.
  8. A practical strategy for structural modification of aliphatic scaffolds via palladium-catalyzed picolinamide directed remote functionalization of unactivated C(sp3)-H bonds: synthesis of (+)-obafluorin, G. He and G. Chen, Angew. Chem. Int. Ed. 201150, 5192-5196.
  9.  Chemical synthesis of a bis-phosphorylated mannose-6-phosphate N-glycan and its facile mono-conjugation with human carbonic anhydrase II for in vivo fluorescence imaging, Y.-P. Liu, Y.-M. Chan, J.-H. Wu, C. Chen, A. Benesi, J. Hu, Y.-M. Wang, and G. Chen, ChemBioChem 201112, 685-690.
  10.  Total synthesis of celogentin C via stereoselective C-H activation, Y.-Q. Feng and G. Chen, Angew. Chem., Int. Ed. 201049, 958-961.