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元素有机化学国家重点实验室(南开大学)

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学术交流

学术报告-Marine Natural Products Synthesis: A Platform for Chemical and Biological Discovery

发布单位:元素有机化学国家重点实验室   发布时间:2017/05/15    浏览次数:340次


报告题目:Marine Natural Products Synthesis: A Platform for Chemical and Biological Discovery
报告人:    Joshua Pierce 教授
                  美国北卡州立大学
报告时间:2017年5月18日(周四)下午4:00
报告地点:石先楼二楼学术报告厅

摘要:
    Marine natural products often have complex structures and potent biological activities;however, little is understood regarding how their molecular structure correlates with function or what biological targets or pathways are involved. Through rapid and efficient chemical syntheses of bioactive marine natural products we are able prepare ample quantities of material to explore both structure-activity relationships as well as target identification studies. In all our efforts, a key focus is the development of short and scalable approaches, accomplished by new reaction development and strategic synthetic planning. Specifically, the monanchocidin, synoxazolidinone and lipoxazolidinone families of natural products will be discussed leading to novel synthetic derivatives that serve as lead structures for infectious disease and cancer chemical probe and therapeutic development.

附:Joshua Pierce教授_CV